Evidence map›Paper›PMID 27818247›Full record

ArticleExperimental cell research2016

GAPDH binds Akt to facilitate cargo transport in the early secretory pathway.

Ellen J Tisdale, Nikunj K Talati, Cristina R Artalejo, Assia Shisheva

Abstract read
In one paragraph

Article in Experimental cell research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 24 citations in OpenAlex.

  1. Targeting Moonlighting Enzymes in Cancer.Molecules (Basel, Switzerland) · 2024
    Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. AtCAP2 is crucial for lytic vacuole biogenesis during germination by positively regulating vacuolar protein trafficking.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ellen J TisdaleDepartment of Pharmacology, Wayne State University School of Medicine, 540 E. Canfield Ave., 6374 Scott Hall, Detroit, MI 48201, USA. Electronic address: etisdale@med.wayne.edu.
Nikunj K TalatiDepartment of Pharmacology, Wayne State University School of Medicine, 540 E. Canfield Ave., 6374 Scott Hall, Detroit, MI 48201, USA.
Cristina R ArtalejoDepartment of Pharmacology, Wayne State University School of Medicine, 540 E. Canfield Ave., 6374 Scott Hall, Detroit, MI 48201, USA.
Assia ShishevaDepartment of Physiology, Wayne State University School of Medicine, 540 E. Canfield Ave., 6374 Scott Hall, Detroit, MI 48201, USA.
Wayne State University · US

Funding

FUNCTIONS OF ADIPOCYTE PIKFYVE AND ITS LIPID PRODUCTSR01DK058058 · NIDDK · WAYNE STATE UNIVERSITY · PI SHISHEVA, ASSIA · 2002 to 2011
$2.8M
VTC Events Mediated by the Rab2 ComplexR01GM068813 · NIGMS · WAYNE STATE UNIVERSITY · PI TISDALE, ELLEN J · 2005 to 2010
$1.2M
NIDDK NIH HHS R01 DK058058NIGMS NIH HHS R01 GM068813
6 · The paper itself

Abstract

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) undergoes numerous post-translational modifications, which impart new function and influence intracellular location. For example, atypical PKC ι/λ phosphorylates GAPDH that locates to vesicular tubular clusters and is required for retrograde membrane trafficking in the early secretory pathway. GAPDH is also required in the endocytic pathway; substitution of Pro

Indexed as

AnimalsCricetinaeCricetulusEndoplasmic ReticulumGlyceraldehyde-3-Phosphate DehydrogenasesGolgi ApparatusHeLa CellsHumansMicrotubulesProtein BindingProtein Processing, Post-TranslationalProtein TransportProto-Oncogene Proteins c-aktRatsSecretory PathwayGlyceraldehyde-3-Phosphate DehydrogenasesProto-Oncogene Proteins c-aktAktGAPDHIntracellular traffickingMicrotubulesRab1Rab2

Identifiers

PMID27818247
PMCPMC5129630
OpenAlexW2547580682

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.