ArticleAmerican journal of ophthalmology2017
Retinal Microvascular Network and Microcirculation Assessments in High Myopia.
Article in American journal of ophthalmology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04443231 (Prospective Clinical Study of Retinal Microvascular Alteration After ICL Implantation), which is not on this map. Cited by 129 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prospective Clinical Study of Retinal Microvascular Alteration After ICL Implantation
Who cites it
129 citing papers in PubMed, 1 synthesis or guideline pooled it, 232 citations in OpenAlex.
- Correlation between refractive errors and ocular biometric parameters in children and adolescents: a systematic review and meta-analysis.BMC ophthalmology · 2023Pooled it
- Effects of Chinese Acupoint Eye Exercise on Ocular Biological Parameters.Translational vision science & technology · 2025Trial
- Decreased retinal capillary density as a beneficial response to 24-week high-speed circuit resistant training in healthy older adults.Microvascular research · 2024Trial
- Biphasic Change in Retinal Arterial Hemodynamics Amidst Systematic Perfusion Decline With Increasing Degree of Myopia.Investigative ophthalmology & visual science · 2026Article
- Molecular and Biomechanical Changes in the Anterior Segment of High Myopic Eyes.Annals of biomedical engineering · 2026Review
- Alterations in Macular and Peripapillary Vessel Density Following Implantable Collamer Lens Surgery in Highly Myopic Eyes and Their Potential Association with 2-Year Axial Length Changes.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- Short-Term Choroidal and Retinal Structural Changes in Myopic Children Treated with 0.05% Atropine.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- Associations between axial length and optical coherence tomography angiography biomarkers.International journal of retina and vitreous · 2025Article
- Characteristics of Retinal Oxygen Kinetics and Blood Flow in Myopia of Different Degrees.Investigative ophthalmology & visual science · 2025Article
- Associations Between Retinal Microvasculature, Orbital Blood Flow, and Cerebral Blood Flow in Healthy Adults.Investigative ophthalmology & visual science · 2025Article
- Retinal Neurovascular Signatures in Parkinson's Disease.Investigative ophthalmology & visual science · 2025Article
- Changes in choriocapillaris blood flow density and associated factors affecting axial elongation in Chinese children and adolescents with mild to moderate myopia: a cross-sectional study.BMC ophthalmology · 2025Article
- Correlation Between Relative Peripheral Refraction and Efficacy of Myopia Control After Wearing Multifocal Soft Contact Lenses in Children.Ophthalmology and therapy · 2025Article
- Quadrant asymmetry alteration of deep retinal capillary plexus degeneration in pathological myopia.Journal of translational medicine · 2025Article
- Comparative analysis of the optic nerve microvasculature between different optic disc phenotypes of normal-tension glaucoma patients.BMC ophthalmology · 2025Article
- Optical coherence tomography angiography compared with optical coherence tomography for detection of glaucoma progression with high myopia.Scientific reports · 2025Article
- The Significance of OCTA in Studying Vessel Density and Retinal Thickness in Individuals with Myopia.Medicina (Kaunas, Lithuania) · 2025Article
- The Effect of Partial Sleep Deprivation on Retinal Microvasculature in Myopia With Different Axial Lengths.Investigative ophthalmology & visual science · 2025Article
- Global trends and hotspots in artificial intelligence for high myopia: a bibliometric analysis.Frontiers in medicine · 2025Article
- Differences in macular structure and microvasculature between high myopia and non-high myopia.Frontiers in medicine · 2025Article
69 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
purposeTo investigate the changes of the retinal microvascular network and microcirculation in high myopia.
designA cross-sectional, matched, comparative clinical study.
participantsTwenty eyes of 20 subjects with nonpathological high myopia (28 ± 5 years of age) with a refractive error of -6.31 ± 1.23 D (mean ± SD) and 20 eyes of 20 age- and sex-matched control subjects (30 ± 6 years of age) with a refractive error of -1.40 ± 1.00 D were recruited.
methodsOptical coherence tomography angiography (OCTA) was used to image the retinal microvascular network, which was later quantified by fractal analysis (box counting [D
resultsThe density of both superficial and deep microvascular plexuses was significantly decreased in the myopia group in comparison to the controls (P < .05). The decrease of the microvessel density of the annular zone (0.6-2.5 mm), measured as D
conclusionsRetinal microvascular decrease was observed in the high myopia subjects, whereas the retinal microvessel BFV remained unchanged. The retinal microvascular network alteration may be attributed to ocular elongation that occurs with the progression of myopia. The novel quantitative analyses of the retinal microvasculature may help to characterize the underlying pathophysiology of myopia and enable early detection and prevention of myopic retinopathy.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.