ArticleCurrent biology : CB2016
Molecular Genetic Contributions to Social Deprivation and Household Income in UK Biobank.
Article in Current biology : CB, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 1 of them a synthesis that pooled it.
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Who cites it
90 citing papers in PubMed, 1 synthesis or guideline pooled it, 204 citations in OpenAlex.
- Gene-environment correlations and causal effects of childhood maltreatment on physical and mental health: a genetically informed approach.The lancet. Psychiatry · 2021Pooled it
- A cross-sectional and prospective examination of alcohol use and misuse among adult twin and sibling pairs discordant for neighborhood socio-economic disadvantage.Addiction (Abingdon, England) · 2026Article
- Characteristics of parks associated with depression in women only: a cross-sectional study of 329,363 adults.BMC medicine · 2026Article
- Distinguishing specific from broad genetic associations between external correlates and common factors.Bioinformatics (Oxford, England) · 2025Article
- Incorporating additive genetic effects and linkage disequilibrium information to discover gene-environment interactions using BV-LDER-GE.Genome biology · 2025Article
- Polygenic scores for depression are associated with indices of neighborhood adversity.Journal of psychopathology and clinical science · 2025Article
- Deciphering the influence of socioeconomic status on brain structure: insights from Mendelian randomization.Molecular psychiatry · 2025Article
- Social and Behavioral Genomics: On the Ethics of the Research and Its Downstream Applications.Annual review of genomics and human genetics · 2025Review
- Intergenerational transmission of complex traits and the offspring methylome.Molecular psychiatry · 2025Article
- Beyond predictive RAmerican journal of human genetics · 2025Article
- Distinguishing Specific from Broad Genetic Associations between External Correlates and Common Factors.bioRxiv : the preprint server for biology · 2025Article
- Multi-ancestry genetic architecture of sleep duration and its relationship to other sleep and psychiatric phenotypes.medRxiv : the preprint server for health sciences · 2025Article
- Associations between common genetic variants and income provide insights about the socio-economic health gradient.Nature human behaviour · 2025Article
- Contribution of copy number variations to education, socioeconomic status and cognition from a genome-wide study of 305,401 subjects.Molecular psychiatry · 2025Article
- Investigating cross-sectional and longitudinal relationships between brain structure and distinct dimensions of externalizing psychopathology in the ABCD sample.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Polygenic prediction of occupational status GWAS elucidates genetic and environmental interplay in intergenerational transmission, careers and health in UK Biobank.Nature human behaviour · 2025Article
- Exome sequencing identifies genes for socioeconomic status in 350,770 individuals.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Genetic associations between non-cognitive skills and academic achievement over development.Nature human behaviour · 2024Article
- Principled distillation of UK Biobank phenotype data reveals underlying structure in human variation.Nature human behaviour · 2024Article
- An epidemiological study of season of birth, mental health, and neuroimaging in the UK Biobank.PloS one · 2024Article
30 more citing papers are in PubMed but not listed here.
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10 authors at 6 institutions in 3 countries.
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Abstract
Individuals with lower socio-economic status (SES) are at increased risk of physical and mental illnesses and tend to die at an earlier age [1-3]. Explanations for the association between SES and health typically focus on factors that are environmental in origin [4]. However, common SNPs have been found collectively to explain around 18% of the phenotypic variance of an area-based social deprivation measure of SES [5]. Molecular genetic studies have also shown that common physical and psychiatric diseases are partly heritable [6]. It is possible that phenotypic associations between SES and health arise partly due to a shared genetic etiology. We conducted a genome-wide association study (GWAS) on social deprivation and on household income using 112,151 participants of UK Biobank. We find that common SNPs explain 21% of the variation in social deprivation and 11% of household income. Two independent loci attained genome-wide significance for household income, with the most significant SNP in each of these loci being rs187848990 on chromosome 2 and rs8100891 on chromosome 19. Genes in the regions of these SNPs have been associated with intellectual disabilities, schizophrenia, and synaptic plasticity. Extensive genetic correlations were found between both measures of SES and illnesses, anthropometric variables, psychiatric disorders, and cognitive ability. These findings suggest that some SNPs associated with SES are involved in the brain and central nervous system. The genetic associations with SES obviously do not reflect direct causal effects and are probably mediated via other partly heritable variables, including cognitive ability, personality, and health.
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