ArticleCurrent biology : CB2016
Auxin Acts through MONOPTEROS to Regulate Plant Cell Polarity and Pattern Phyllotaxis.
Article in Current biology : CB, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 1 of them a synthesis that pooled it.
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Who cites it
64 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Overview of molecular mechanisms of plant leaf development: a systematic review.Frontiers in plant science · 2023Pooled it
- SERRATE Regulates Floral Meristem Activity by Antagonizing SHOOT MERISTEMLESS and Repressing Cytokinin Signaling.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- TMO5 regulates PIN1 polarity convergence and organogenesis downstream of MONOPTEROS in the Arabidopsis shoot.Development (Cambridge, England) · 2025Article
- MONOPTEROS isoform MP11ir plays a role during somatic embryogenesis in Arabidopsis thaliana.Plant physiology · 2025Article
- Mutual inhibition between EPFL2 and auxin extends the intervals of periodic leaf morphogenesis.Nature communications · 2025Article
- Computational modeling of plant root development: the art and the science.The New phytologist · 2025Review
- Auxin-mediated stress relaxation in pericycle and endoderm remodeling drives lateral root initiation.Biophysical journal · 2025Article
- Article
- KNUCKLES regulates floral meristem termination by controlling auxin distribution and cytokinin activity.The Plant cell · 2024Article
- Silencing of theInternational journal of molecular sciences · 2024Article
- Multiplexed in situ hybridization reveals distinct lineage identities for major and minor vein initiation during maize leaf development.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- A CUC1/auxin genetic module links cell polarity to patterned tissue growth and leaf shape diversity in crucifer plants.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- The Function of Florigen in the Vegetative-to-Reproductive Phase Transition in and around the Shoot Apical Meristem.Plant & cell physiology · 2024Review
- Article
- Game of thrones among AUXIN RESPONSE FACTORs-over 30 years of MONOPTEROS research.Journal of experimental botany · 2023Review
- Article
- Stiffness transitions in new walls post-cell division differ betweenProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Stem Cells: Engines of Plant Growth and Development.International journal of molecular sciences · 2023Review
- A Common Molecular Signature Indicates the Pre-Meristematic State of Plant Calli.International journal of molecular sciences · 2023Review
- Flowering also has to end: knowns and unknowns of reproductive arrest in monocarpic plants.Journal of experimental botany · 2023Review
4 more citing papers are in PubMed but not listed here.
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6 authors.
Funding
Abstract
The periodic formation of plant organs such as leaves and flowers gives rise to intricate patterns that have fascinated biologists and mathematicians alike for hundreds of years [1]. The plant hormone auxin plays a central role in establishing these patterns by promoting organ formation at sites where it accumulates due to its polar, cell-to-cell transport [2-6]. Although experimental evidence as well as modeling suggest that feedback from auxin to its transport direction may help specify phyllotactic patterns [7-12], the nature of this feedback remains unclear [13]. Here we reveal that polarization of the auxin efflux carrier PIN-FORMED 1 (PIN1) is regulated by the auxin response transcription factor MONOPTEROS (MP) [14]. We find that in the shoot, cell polarity patterns follow MP expression, which in turn follows auxin distribution patterns. By perturbing MP activity both globally and locally, we show that localized MP activity is necessary for the generation of polarity convergence patterns and that localized MP expression is sufficient to instruct PIN1 polarity directions non-cell autonomously, toward MP-expressing cells. By expressing MP in the epidermis of mp mutants, we further show that although MP activity in a single-cell layer is sufficient to promote polarity convergence patterns, MP in sub-epidermal tissues helps anchor these polarity patterns to the underlying cells. Overall, our findings reveal a patterning module in plants that determines organ position by orienting transport of the hormone auxin toward cells with high levels of MP-mediated auxin signaling. We propose that this feedback process acts broadly to generate periodic plant architectures.
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