ArticleCurrent biology : CB2016
The TRP Channels Pkd2, NompC, and Trpm Act in Cold-Sensing Neurons to Mediate Unique Aversive Behaviors to Noxious Cold in Drosophila.
Article in Current biology : CB, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
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Who cites it
70 citing papers in PubMed.
- Cold sensing by a glutamate receptor drives avoidance behavior in Drosophila larvae.Current biology : CB · 2026Article
- Multimodal targets of (-)-α-thujone mediating avoidance behavior of a stored-products pest, Tribolium castaneum, in response to irritant stimuli.Pest management science · 2026Article
- TRP channel activation and cholinergic signaling in insect thermoregulation: evidence from the American cockroach.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2026Article
- Comparative Transcriptome Analysis of the Abdominal Ganglion Reveals Molecular Networks and Key Genes Underlying Thermal Tolerance in Red Swamp Crayfish (Animals : an open access journal from MDPI · 2026Article
- Genome-wide identification and temperature-responsive expression profiling of TRP gene family in red swamp crayfish (Procambarus clarkii).BMC genomics · 2026Article
- Evolution in metazoans of the TRPM channel family involves multiple gains and losses of genes and domains.Molecular biology and evolution · 2026Article
- Ether phospholipids modulate somatosensory responses by tuning multiple receptor functions iniScience · 2026Article
- Identification of molecular nociceptors in Octopus vulgaris through functional characterisation in Caenorhabditis elegans.Biology open · 2026Article
- ILP4 and InR regulate paclitaxel-induced hypersensitivity differently inMolecular biology of the cell · 2026Article
- TRP Channels from Sensory Coding to Physiology.Metabolites · 2025Review
- Modelling Neural Disorders with theBiomolecules · 2025Review
- Identification of candidate mechanosensory transduction channels in the aquatic insect Protohermes xanthodes (Megaloptera: Corydalidae) by transcriptome analysis.Journal of insect science (Online) · 2025Article
- From nociception in aneural animals to human suffering: toward a comparative biology of pain.The Journal of experimental biology · 2025Review
- Neural substrates of cold nociception ineLife · 2025Article
- Cold-Sensing TRP Channels and Temperature Preference Modulate Ovarian Development in the Model OrganismInternational journal of molecular sciences · 2025Article
- Heat-off responses of epidermal cells sensitizebioRxiv : the preprint server for biology · 2025Article
- Article
- Expression profiles analysis and roles in immunity of transient receptor potential (TRP) channel genes in Spodoptera frugiperda.BMC genomics · 2025Article
- TRPγ regulates lipid metabolism througheLife · 2025Article
- HL-TRP channel is required for various repellents for the parthenogenetic Haemaphysalis longicornis.Parasites & vectors · 2025Article
10 more citing papers are in PubMed but not listed here.
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11 authors.
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Abstract
The basic mechanisms underlying noxious cold perception are not well understood. We developed Drosophila assays for noxious cold responses. Larvae respond to near-freezing temperatures via a mutually exclusive set of singular behaviors-in particular, a full-body contraction (CT). Class III (CIII) multidendritic sensory neurons are specifically activated by cold and optogenetic activation of these neurons elicits CT. Blocking synaptic transmission in CIII neurons inhibits CT. Genetically, the transient receptor potential (TRP) channels Trpm, NompC, and Polycystic kidney disease 2 (Pkd2) are expressed in CIII neurons, where each is required for CT. Misexpression of Pkd2 is sufficient to confer cold responsiveness. The optogenetic activation level of multimodal CIII neurons determines behavioral output, and visualization of neuronal activity supports this conclusion. Coactivation of cold- and heat-responsive sensory neurons suggests that the cold-evoked response circuitry is dominant. Our Drosophila model will enable a sophisticated molecular genetic dissection of cold nociceptive genes and circuits.
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