Evidence map›Paper›PMID 27818172›Full record

ReviewBiochimica et biophysica acta. Biomembranes2017

Regulation of KCNQ/Kv7 family voltage-gated K

Keenan C Taylor, Charles R Sanders

Open access · greenAbstract readReview
In one paragraph

Review in Biochimica et biophysica acta. Biomembranes, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. The Concise Guide to PHARMACOLOGY 2023/24: Ion channels.British journal of pharmacology · 2023
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Polyunsaturated Fatty Acids as Modulators of KFrontiers in physiology · 2020
    Review
  15. Kv7 Channels in Lung Diseases.Frontiers in physiology · 2020
    Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Keenan C TaylorDepartment of Biochemistry, Vanderbilt University, Nashville, TN, USA; Center for Structural Biology, Vanderbilt University, Nashville, TN, USA.
Charles R SandersDepartment of Biochemistry, Vanderbilt University, Nashville, TN, USA; Center for Structural Biology, Vanderbilt University, Nashville, TN, USA; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address: chuck.sanders@vanderbilt.edu.
Vanderbilt University · US

Funding

Decrypting Variants of Uncertain Significance in Long-QT SyndromeR01HL122010 · NHLBI · VANDERBILT UNIVERSITY · PI GEORGE, ALFRED L., SANDERS, CHARLES R · 2014 to 2025
$15.5M
Cholesterol and the Amyloid Precursor ProteinR01GM106672 · NIGMS · VANDERBILT UNIVERSITY · PI SANDERS, CHARLES R · 2013 to 2016
$1.2M
Structure Determination of the Closed-State Human K+ Channel, KCNQ1, Voltage Senor DomainF32GM117770 · NIGMS · VANDERBILT UNIVERSITY · PI TAYLOR, KEENAN · 2016 to 2017
$111k
NHLBI NIH HHS R01 HL122010NIGMS NIH HHS F32 GM117770NIGMS NIH HHS R01 GM106672NIH HHS T32 NS00749
6 · The paper itself

Abstract

Many years of studies have established that lipids can impact membrane protein structure and function through bulk membrane effects, by direct but transient annular interactions with the bilayer-exposed surface of protein transmembrane domains, and by specific binding to protein sites. Here, we focus on how phosphatidylinositol 4,5-bisphosphate (PIP

Indexed as

Amino Acid SequenceBinding SitesCell MembraneEpilepsy, Benign NeonatalFatty Acids, UnsaturatedHearing Loss, BilateralHumansHydrophobic and Hydrophilic InteractionsKCNQ1 Potassium ChannelLong QT SyndromeMembrane LipidsModels, MolecularPhosphatidylinositol 4,5-DiphosphateProtein BindingProtein IsoformsProtein Structure, SecondaryFatty Acids, UnsaturatedKCNQ1 Potassium ChannelKCNQ1 protein, humanMembrane LipidsPhosphatidylinositol 4,5-DiphosphateProtein IsoformsAnnularChannelKCNQ1Kv7.1LipidsMembranePIP2PotassiumPUFAVoltage-gated

Identifiers

PMID27818172
PMCPMC5305565
OpenAlexW2547454016

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.