Evidence map›Paper›PMID 27817870›Full record

ReviewPlacenta2016

Biological features of placental programming.

Kent L Thornburg, Kevin Kolahi, Melinda Pierce, Amy Valent, Rachel Drake, Samantha Louey

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Placenta, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
7.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Observational
  8. Article
  9. Article
  10. Article
  11. Measuring intrauterine growth in healthy pregnancies using quantitative magnetic resonance imaging.Journal of perinatology : official journal of the California Perinatal Association · 2022
    Article
  12. Article
  13. Review
  14. Article
  15. Observational
  16. Review
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Kent L ThornburgKnight Cardiovascular Institute, Oregon Health and Science University, Portland, OR, USA; Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR, USA; Department of Medicine, Oregon Health and Science University, Portland, OR, USA; Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, OR, USA; Moore Institute for Nutrition and Wellness, Oregon Health and Science University, Portland, OR, USA. Electronic address: thornbur@ohsu.edu.
Kevin KolahiKnight Cardiovascular Institute, Oregon Health and Science University, Portland, OR, USA; Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR, USA.
Melinda PierceDepartment of Pediatrics, Oregon Health and Science University, Portland, OR, USA.
Amy ValentDepartment of Obstetrics and Gynecology, Oregon Health and Science University, Portland, OR, USA.
Rachel DrakeKnight Cardiovascular Institute, Oregon Health and Science University, Portland, OR, USA.
Samantha LoueyKnight Cardiovascular Institute, Oregon Health and Science University, Portland, OR, USA; Moore Institute for Nutrition and Wellness, Oregon Health and Science University, Portland, OR, USA.
Oregon Health & Science University · US

Funding

ULTRASOUND IMAGING COREP01HD034430 · NICHD · OREGON HEALTH & SCIENCE UNIVERSITY · PI THORNBURG, KENT L.R. · 1997 to 2017
$20.7M
OHSU Women's Reproductive Health Research K12 ProgramK12HD085809 · NICHD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Aaron B Caughey · 2015 to 2026
$4.0M
Real-time Assessment of Fatty Acid Transit in the Human Placental SyncytiotrophoblastF30HD084095 · NICHD · OREGON HEALTH & SCIENCE UNIVERSITY · PI KOLAHI, KEVIN · 2015 to 2018
$170k
NICHD NIH HHS F30 HD084095NICHD NIH HHS K12 HD085809NICHD NIH HHS P01 HD034430
6 · The paper itself

Abstract

The placenta is a key organ in programming the fetus for later disease. This review outlines nine of many structural and physiological features of the placenta which are associated with adult onset chronic disease. 1) Placental efficiency relates the placental mass to the fetal mass. Ratios at the extremes are related to cardiovascular disease risk later in life. 2) Placental shape predicts a large number of disease outcomes in adults but the regulators of placental shape are not known. 3) Non-human primate studies suggest that at about mid-gestation, the placenta becomes less plastic and less able to compensate for pathological stresses. 4) Recent studies suggest that lipids have an important role in regulating placental metabolism and thus the future health of offspring. 5) Placental inflammation affects nutrient transport to the fetus and programs for later disease. 6) Placental insufficiency leads to inadequate fetal growth and elevated risks for later life disease. 7) Maternal height, fat and muscle mass are important in combination with placental size and shape in predicting adult disease. 8) The placenta makes a host of hormones that influence fetal growth and are related to offspring disease. Unfortunately, our knowledge of placental growth and function lags far behind that of other organs. An investment in understanding placental growth and function will yield enormous benefits to human health because it is a key player in the origins of the most expensive and deadly chronic diseases that humans face.

Indexed as

AnimalsFemaleFetal DevelopmentHumansMaternal-Fetal ExchangePlacentaPlacental InsufficiencyPregnancyPrenatal Exposure Delayed EffectsBirthweightChronic diseaseInflammationPlacentaProgrammingTrophoblast

Identifiers

PMID27817870
PMCPMC5278807
OpenAlexW2532859617

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.