Reply to: Antidepressant Actions of Ketamine Versus Hydroxynorketamine.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

16 citing papers in PubMed.

1. From depression to bone health: examining the skeletal effects of classical and rapid-acting antidepressants.The international journal of neuropsychopharmacology · 2026
   Review
2. A Time-Sensitive Plasticity Distinguishes the Rapid and Sustained Synaptic Actions of Ketamine from Its (2The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
   Article
3. Ketamine and Hydroxynorketamine as Novel Pharmacotherapies for the Treatment of Opioid Use Disorders.Biological psychiatry · 2025
   Review
4. Ketamine metabolism via hepatic CYP450 isoforms contributes to its sustained antidepressant actions.Neuropharmacology · 2024
   Article
5. Rodent ketamine depression-related research: Finding patterns in a literature of variability.Behavioural brain research · 2019
   Review
6. A Major Role for the Lateral Habenula in Depressive Illness: Physiologic and Molecular Mechanisms.Frontiers in psychiatry · 2019
   Review
7. Ketamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms.Pharmacological reviews · 2018
   Review
8. Antidepressant Efficacy and Tolerability of Ketamine and Esketamine: A Critical Review.CNS drugs · 2018
   Review
9. Mechanisms of ketamine action as an antidepressant.Molecular psychiatry · 2018
   Review
10. Lack of metabolism in (R)-ketamine's antidepressant actions in a chronic social defeat stress model.Scientific reports · 2018
    Article
11. Convergent Mechanisms Underlying Rapid Antidepressant Action.CNS drugs · 2018
    Review
12. Hyperforin Potentiates Antidepressant-Like Activity of Lanicemine in Mice.Frontiers in molecular neuroscience · 2018
    Article
13. Effects of a ketamine metabolite on synaptic NMDAR function.Nature · 2017
    Article
14. What's the Buzz About Hydroxynorketamine? Is It the History, the Story, the Debate, or the Promise?Biological psychiatry · 2017
    Article
15. Hydroxynorketamine: Implications for the NMDA Receptor Hypothesis of Ketamine's Antidepressant Action.Chronic stress (Thousand Oaks, Calif.)
    Article
16. Ketamine, but Not the NMDAR Antagonist Lanicemine, Increases Prefrontal Global Connectivity in Depressed Patients.Chronic stress (Thousand Oaks, Calif.)
    Article

Corrections and comments

• Commented on by
  What's the Buzz About Hydroxynorketamine? Is It the History, the Story, the Debate, or the Promise?2017
• Comment on
  NMDAR inhibition-independent antidepressant actions of ketamine metabolites.2016
• Comment on
  Antidepressant Actions of Ketamine Versus Hydroxynorketamine.2017

Authors and funding

9 authors.

Funding

Abstract

PubMed holds no abstract for this paper.

Indexed as