Evidence map›Paper›PMID 27817778›Full record

ArticleZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics2016

[Association between interleukin-1β C+3953T and genetic susceptibility to spontaneous preterm birth: a case-control study].

Xiao Yang, Wei Peng, Li-Na Zhu, Xiao-Ai Zhang, Yan Wang

Abstract read
In one paragraph

Article in Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Xiao YangDevelopmental Biology Laboratory, Baiyi Children's Hospital Affiliated to Chinese People's Liberation Army General Hospital, Beijing 100700, China. 001wangyan@sina.com.
Wei Peng
Li-Na Zhu
Xiao-Ai Zhang
Yan Wang

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo study the association between interleukin-1β (IL-1β) C+3953T and genetic susceptibility to spontaneous preterm birth (SPTB).

methodsIn this case-control study, 753 SPTB neonates were enrolled in the case group and 681 full-term neonates were enrolled in the control group. The latest Sequenom MassARRAY®SNP detection technique was used for the typing of single nucleotide polymorphisms (SNP) of IL-1β C+3953T.

resultsCompared with those carrying CC genotype of IL-1β C+3953T, the neonates who carried at least one T allele (CT+TT genotype) had significantly increased risks of SPTB, SPTB complicated by premature rupture of membranes, and mild preterm birth.

conclusionsIn the Chinese population, IL-1β C+3953T has significant genetic association with an increased risk of SPTB. The identification of this SNP helps to prevent SPTB and clarify the causes and pathogenesis of SPTB.

Indexed as

Genetic Predisposition to DiseasePolymorphism, Single NucleotideCase-Control StudiesFemaleHumansInfant, NewbornInterleukin-1betaMalePremature BirthInterleukin-1beta

Identifiers

PMID27817778
PMCPMC7389849

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.