Evidence map›Paper›PMID 27817159›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2017

Characterization of [

Kai-Chun Yang, Vladimir Stepanov, Nahid Amini, Stefan Martinsson, Akihiro Takano, Jacob Nielsen, Christoffer Bundgaard, Benny Bang-Andersen, Sarah Grimwood, Christer Halldin and 2 more

Open access · hybridAbstract read
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 3 countries.

Kai-Chun YangDepartment of Clinical Neuroscience, Center for Psychiatric Research, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden. kai-chun.yang@ki.se.ORCID http://orcid.org/0000-0001-8198-2509
Vladimir StepanovDepartment of Clinical Neuroscience, Center for Psychiatric Research, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Nahid AminiDepartment of Clinical Neuroscience, Center for Psychiatric Research, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Stefan MartinssonDepartment of Clinical Neuroscience, Center for Psychiatric Research, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Akihiro TakanoDepartment of Clinical Neuroscience, Center for Psychiatric Research, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Jacob NielsenSynaptic Transmission, H. Lundbeck A/S, Valby, Denmark.
Christoffer BundgaardDiscovery Chemistry and DMPK, H. Lundbeck A/S, Valby, Denmark.
Benny Bang-AndersenDiscovery Chemistry and DMPK, H. Lundbeck A/S, Valby, Denmark.
Sarah GrimwoodNeuroscience and Pain Research Unit, Pfizer Inc., Cambridge, MA, USA.
Christer HalldinDepartment of Clinical Neuroscience, Center for Psychiatric Research, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Lars FardeDepartment of Clinical Neuroscience, Center for Psychiatric Research, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Sjoerd J FinnemaDepartment of Clinical Neuroscience, Center for Psychiatric Research, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Karolinska University Hospital · SELundbeck (Denmark) · DKPfizer (United States) · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

purpose[

methodsA total of 11 PET measurements, seven baseline and four following pretreatment with unlabeled Lu AE92686 or the structurally unrelated PDE10A inhibitor MP-10, were performed in five NHPs using a high resolution research tomograph (HRRT). [

resultsRegional time-activity curves were best described with the two-tissue compartment model (2TCM). However, the distribution volume (V

conclusionsThe method proposed for quantification of [

Indexed as

AnimalsBrainFemaleHumansIsotope LabelingLigandsMacaca fascicularisMetabolic Clearance RateMolecular ImagingOrgan SpecificityPhosphodiesterase InhibitorsPhosphoric Diester HydrolasesPositron-Emission TomographyPyridinesRadiopharmaceuticalsTissue DistributionLigandsLu AE92686PDE10A protein, humanPhosphodiesterase InhibitorsPhosphoric Diester HydrolasesPyridinesRadiopharmaceuticalsTriazoles[11C]Lu AE92686MonkeyMP-10PETPhosphodiesterase 10ASubstantia nigra

Identifiers

PMID27817159
PMCPMC5215309
OpenAlexW2548475738

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.