SynthesisEndocrine2017
Mortality in adults with hypopituitarism: a systematic review and meta-analysis.
Synthesis in Endocrine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
63 citing papers in PubMed, 3 syntheses or guidelines pooled it, 111 citations in OpenAlex.
- The oxytocin system in patients with craniopharyngioma: A systematic review.Frontiers in neuroendocrinology · 2025Pooled it
- Endocrine disorders after primary gamma knife radiosurgery for pituitary adenomas: A systematic review and meta-analysis.Pituitary · 2022Pooled it
- Non-alcoholic fatty liver disease across endocrinopathies: Interaction with sex hormones.Frontiers in endocrinology · 2022Pooled it
- Prognostic factors in the surgical treatment of non-functioning pituitary adenomas: a retrospective cohort study.Archives of endocrinology and metabolism · 2026Article
- Secondary Hypogonadism and Effects of Testosterone Replacement Therapy on Cardiovascular Events.The Journal of clinical endocrinology and metabolism · 2026Article
- Sex differences in clinical and metabolic outcomes of glucocorticoid replacement therapy in adrenal insufficiency.Pituitary · 2026Review
- Central hypothyroidism and cardiovascular disease: a Spanish cohort observational study.Hormones (Athens, Greece) · 2026Observational
- A Case Report of Growth Hormone-Secreting Pituitary Adenoma Complicated by Apoplexy With Atypical Clinical Presentation.Case reports in medicine · 2026Article
- Determinants of QTc Interval Prolongation in Patients with Hypopituitarism and Other Pituitary Disorders.Biomedicines · 2025Article
- Hypopituitarism: genetic, developmental, and acquired etiologies with a focus on the emerging concept of autoimmune hypophysitis.Endocrine journal · 2025Review
- Sex-Specific Cardiovascular Risks and Mortality in Patients with Panhypopituitarism: A Nationwide Cohort Study.Endocrinology and metabolism (Seoul, Korea) · 2025Article
- Long-term quality of life and hypothalamic dysfunction after craniopharyngioma.Journal of neuro-oncology · 2025Review
- Pituitary adenomas: biology, nomenclature and clinical classification.Reviews in endocrine & metabolic disorders · 2025Review
- Long-Term IGF-1 Maintenance in the Upper-Normal Range Has Beneficial Effect on Low-Grade Inflammation Marker in Adults with Growth Hormone Deficiency.International journal of molecular sciences · 2025Article
- Sheehan syndrome: a current approach to a dormant disease.Pituitary · 2025Review
- Abnormal Blood Pressure Dipping Pattern in Women with Hypopituitarism Secondary to Sheehan Syndrome: A Case-Control Study.Sisli Etfal Hastanesi tip bulteni · 2025Article
- Biological poisons targeting the pituitary gland: insights across the five kingdoms.Frontiers in endocrinology · 2025Review
- An Update on Advances in Hypopituitarism: Etiology, Diagnosis, and Current Management.Journal of clinical medicine · 2024Review
- Sex Steroid Levels in Women With Hypopituitarism: A Case-controlled Observational Study.The Journal of clinical endocrinology and metabolism · 2024Observational
- A 2024 Update on Growth Hormone Deficiency Syndrome in Adults: From Guidelines to Real Life.Journal of clinical medicine · 2024Review
3 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeHypopituitarism is a rare disorder with significant morbidity. To study the evidence on the association of premature mortality and hypopituitarism.
methodsA comprehensive search of multiple databases: MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and Scopus was conducted through August, 2015. Eligible studies that evaluated patients with hypopituitarism and reported mortality estimates were selected following a predefined protocol. Reviewers, independently and in duplicate, extracted data and assessed the risk of bias.
resultsWe included 12 studies (published 1996-2015) that reported on 23,515 patients. Compared to the general population, hypopituitarism was associated with an overall excess mortality (weighted SMR of 1.55; 95 % CI 1.14-2.11), I
conclusionHypopituitarism may be associated with premature mortality in adults. Risk is particularly higher in women and those diagnosed at a younger age.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.