Evidence map›Paper›PMID 27817105›Full record

ArticleExperimental brain research2017

Neuro-regeneration therapy using human Muse cells is highly effective in a mouse intracerebral hemorrhage model.

Norihito Shimamura, Kiyohide Kakuta, Liang Wang, Masato Naraoka, Hiroki Uchida, Shohei Wakao, Mari Dezawa, Hiroki Ohkuma

Abstract read
PubMed Publisher
In one paragraph

Article in Experimental brain research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 44 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Norihito ShimamuraDepartment of Neurosurgery, Hirosaki University School of Medicine, 5-Zaihuchou, Hirosaki, Aomori, 036-8562, Japan. shimab@hirosaki-u.ac.jp.ORCID 0000-0003-3003-9160
Kiyohide KakutaDepartment of Neurosurgery, Hirosaki University School of Medicine, 5-Zaihuchou, Hirosaki, Aomori, 036-8562, Japan.
Liang WangDepartment of Neurosurgery, Hirosaki University School of Medicine, 5-Zaihuchou, Hirosaki, Aomori, 036-8562, Japan.
Masato NaraokaDepartment of Neurosurgery, Hirosaki University School of Medicine, 5-Zaihuchou, Hirosaki, Aomori, 036-8562, Japan.
Hiroki UchidaDepartment of Stem Cell Biology and Histology, Tohoku University School of Medicine, Sendai, Japan.
Shohei WakaoDepartment of Stem Cell Biology and Histology, Tohoku University School of Medicine, Sendai, Japan.
Mari DezawaDepartment of Stem Cell Biology and Histology, Tohoku University School of Medicine, Sendai, Japan.
Hiroki OhkumaDepartment of Neurosurgery, Hirosaki University School of Medicine, 5-Zaihuchou, Hirosaki, Aomori, 036-8562, Japan.
Hirosaki University · JPTohoku University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A novel type of non-tumorigenic pluripotent stem cell, the Muse cell (multi-lineage, differentiating stress enduring cell), resides in the connective tissue and in cultured mesenchymal stem cells (MSCs) and is reported to differentiate into multiple cell types according to the microenvironment to repair tissue damage. We examined the efficiency of Muse cells in a mouse intracerebral hemorrhage (ICH) model. Seventy μl of cardiac blood was stereotactically injected into the left putamen of immunodeficient mice. Five days later, 2 × 10

Indexed as

Analysis of VarianceAnimalsCell- and Tissue-Based TherapyCell LineCerebral HemorrhageDisease Models, AnimalGreen Fluorescent ProteinsHumansMaze LearningMesenchymal Stem Cell TransplantationMiceMice, SCIDNerve DegenerationNerve Tissue ProteinsNeurologic ExaminationRegenerative MedicineGreen Fluorescent ProteinsNerve Tissue ProteinsCerebral hemorrhageMesenchymal stem cellsNeuronal differentiationNeuronal regenerationPluripotent stem cells

Identifiers

PMID27817105
OpenAlexW2547090267

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.