Evidence map›Paper›PMID 27817040›Full record

ReviewJournal of assisted reproduction and genetics2017

Female infertility, infertility-associated diagnoses, and comorbidities: a review.

Brent Hanson, Erica Johnstone, Jessie Dorais, Bob Silver, C Matthew Peterson, James Hotaling

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of assisted reproduction and genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 130 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
130citing papers in PubMed, 5 pooled it
19.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

130 citing papers in PubMed, 5 syntheses or guidelines pooled it, 292 citations in OpenAlex.

  1. Brazilian Guideline on Menopausal Cardiovascular Health - 2024.Arquivos brasileiros de cardiologia · 2024
    Guideline
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70 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Brent HansonDepartment of Obstetrics and Gynecology, University of Utah, 50 N Medical Drive, Salt Lake City, UT, 84132, USA. brent.hanson@hsc.utah.edu.ORCID http://orcid.org/0000-0001-9671-2843
Erica JohnstoneDepartment of Reproductive Endocrinology and Infertility, University of Utah, Salt Lake City, UT, USA.
Jessie DoraisDepartment of Reproductive Endocrinology and Infertility, University of Utah, Salt Lake City, UT, USA.
Bob SilverDepartment of Obstetrics and Gynecology, University of Utah, 50 N Medical Drive, Salt Lake City, UT, 84132, USA.
C Matthew PetersonDepartment of Reproductive Endocrinology and Infertility, University of Utah, Salt Lake City, UT, USA.
James HotalingDepartment of Surgery - Urology, University of Utah Center for Reconstructive Urology and Men's Health, 675 Arapeen Way, Suite 205, Salt Lake City, UT, 84108, USA.
University of Utah · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe purpose of the study is to evaluate existing literature for possible associations between female infertility, infertility-associated diagnoses, and the following areas of disease: psychiatric disorders, breast cancer, ovarian cancer, endometrial cancer, cardiovascular disease, and metabolic dysfunction.

methodsThe design of the study is a literature review. The patients were women included in 26 selected studies due to a diagnosis of infertility or a reproductive disorder associated with infertility. This study has no interventions, and the main outcome measure is the association between female infertility or a related diagnosis and psychiatric disorders, breast cancer, ovarian cancer, endometrial cancer, cardiovascular disease, and metabolic dysfunction.

resultsFemale infertility and related reproductive disorders may have ramifications for women beyond reproductive health. An analysis of publications shows that women with infertility had higher rates of psychiatric disorders and endometrial cancer than the general population [1-10]. Data is conflicting about whether infertile women are at increased risk for breast cancer and ovarian cancer [7, 8, 10-20]. A generalized diagnosis of infertility was not clearly associated with an increased risk of cardiovascular disease or metabolic dysfunction, but women with infertility related to polycystic ovarian syndrome (PCOS) do appear more likely to develop cardiovascular disease and metabolic disorders such as diabetes than the general population [16, 21-26].

conclusionsFemale infertility and associated diagnoses have overall health implications. Beyond treatment of patients' immediate reproductive needs, healthcare professionals must be aware of the broader health impact of specific causes of infertility in order to provide accurate counseling regarding long-term risk.

Indexed as

AdultComorbidityFemaleFertilization in VitroGenital Neoplasms, FemaleHumansInfertility, FemaleMental DisordersPolycystic Ovary SyndromeReproductionFertility drugsInfertilityIn vitro fertilizationMalignancySomatic health

Identifiers

PMID27817040
PMCPMC5306404
OpenAlexW2548567961

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.