Evidence map›Paper›PMID 27817036›Full record

ArticleJournal of assisted reproduction and genetics2017

Freeze-all cycle for all normal responders?

Matheus Roque, Marcello Valle, Fernando Guimarães, Marcos Sampaio, Selmo Geber

Registry-linked trialOpen access · bronzeAbstract read
In one paragraph

Article in Journal of assisted reproduction and genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03381001 (Influence of Post-thaw Embryo Culture Interval Before Embryo Transfer on Assisted Reproduction Success Rates), which is not on this map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03381001 nacompletednot on this map

Influence of Post-thaw Embryo Culture Interval Before Embryo Transfer on Assisted Reproduction Success Rates

TypeinterventionalSponsorFederal University of Minas GeraisRan2017 to 2019Enrolled268ConditionsInfertilityArmsembryo transfer after thaw and culture, embryo transfer with no culture
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. FreshJBRA assisted reproduction · 2022
    Article
  6. Elevated serum progesterone does not impact euploidy rates in PGT-A patients.Journal of assisted reproduction and genetics · 2021
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Fertility preservation in breast cancer with case-based examples for guidance.Journal of assisted reproduction and genetics · 2020
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. To freeze or not to freeze: heating the debate but cooling the practice?Journal of assisted reproduction and genetics · 2017
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Matheus RoqueORIGEN-Center for Reproductive Medicine, Avenida Rodolfo de Amoedo, 140-Barra da Tijuca, Rio de Janeiro, Brazil. matheusroque@hotmail.com.
Marcello ValleORIGEN-Center for Reproductive Medicine, Avenida Rodolfo de Amoedo, 140-Barra da Tijuca, Rio de Janeiro, Brazil.
Fernando GuimarãesORIGEN-Center for Reproductive Medicine, Avenida Rodolfo de Amoedo, 140-Barra da Tijuca, Rio de Janeiro, Brazil.
Marcos SampaioORIGEN-Center for Reproductive Medicine, Av do Contorno, 7747-Lourdes, Belo Horizonte, Brazil.
Selmo GeberUniversidade Federal de Minas Gerais, Avenida Alfredo Balena, 190, Belo Horizonte, Brazil.
Brazilian College of Animal Reproduction · BRUniversidade Federal de Minas Gerais · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe purpose of this study is to evaluate the freeze-all strategy in subgroups of normal responders, to assess whether this strategy is beneficial regardless of ovarian response, and to evaluate the possibility of implementing an individualized embryo transfer (iET) based on ovarian response.

methodsThis was an observational, cohort study performed in a private IVF center. A total of 938 IVF cycles were included in this study. The patients were submitted to controlled ovarian stimulation (COS) with a gonadotropin-releasing hormone (GnRH) antagonist protocol and a cleavage-stage day 3 embryo transfer. We performed a comparison of outcomes between the fresh embryo transfer (n = 523) and the freeze-all cycles (n = 415). The analysis was performed in two subgroups of patients based on the number of retrieved oocytes: Group 1 (4-9 oocytes) and Group 2 (10-15 oocytes). RESULT(S): In Group 1 (4-9 retrieved oocytes), the implantation rates (IR) were 17.9 and 20.5% (P = 0.259) in the fresh and freeze-all group, respectively; the ongoing pregnancy rates (OPR) were 31 and 33% (P = 0.577) in the fresh and freeze-all group, respectively. In Group 2 (10-15 oocytes), the IR were 22.1 and 30.1% (P = 0.028) and the OPR were 34 and 47% (P = 0.021) in the fresh and freeze-all groups, respectively. CONCLUSION(S): Although the freeze-all policy may be related to better in vitro fertilization (IVF) outcomes in normal responders, these potential advantages decrease with worsening ovarian response. Patients with poorer ovarian response do not benefit from the freeze-all strategy.

Indexed as

CryopreservationEmbryo TransferAdultFemaleFertilization in VitroFreezingGonadotropin-Releasing HormoneHumansOocyte RetrievalOocytesOvulation InductionPregnancyPregnancy OutcomeSperm Injections, IntracytoplasmicGonadotropin-Releasing HormoneDelayed frozen-thawed embryo transferElective frozen-thawed embryo transferEmbryo cryopreservationFreeze-all policyIVF/ICSI

Identifiers

PMID27817036
PMCPMC5306402
OpenAlexW2546728918

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.