Evidence map›Paper›PMID 27816938›Full record

ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2017

Genome-wide Association Study of Parental Life Span.

Toshiko Tanaka, Ambarish Dutta, Luke C Pilling, Luting Xue, Kathryn L Lunetta, Joanne M Murabito, Stefania Bandinelli, Robert Wallace, David Melzer, Luigi Ferrucci

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Genetic and epigenetic regulation of human aging and longevity.Biochimica et biophysica acta. Molecular basis of disease · 2019
    Review
  7. Genetic cartography of longevity in humans and mice: Current landscape and horizons.Biochimica et biophysica acta. Molecular basis of disease · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Toshiko TanakaTranslational Gerontology Branch, National Institute on Aging, Baltimore, Maryland.
Ambarish DuttaPublic Health Foundation of India, Bhubaneswar, Odisha,India.
Luke C PillingEpidemiology and Public Health Group, University of Exeter Medical School, UK.
Luting XueDepartment of Biostatistics, Boston University School of Public Health, Massachusetts.
Kathryn L LunettaNational Heart, Lung and Blood Institute's and Boston University's Framingham Heart Study, Massachusetts.
Joanne M MurabitoNational Heart, Lung and Blood Institute's and Boston University's Framingham Heart Study, Massachusetts.
Stefania BandinelliGeriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy.
Robert WallaceDepartment of Epidemiology, University of Iowa College of Public Health.
David MelzerEpidemiology and Public Health Group, University of Exeter Medical School, UK.
Luigi FerrucciTranslational Gerontology Branch, National Institute on Aging, Baltimore, Maryland.
Boston University · USNational Institute on Aging · USUniversity of Exeter · GBAzienda Sanitaria di Firenze · ITUniversity of Iowa · US

Funding

HRS Yrs29-34: Y33 SSA CoFundingU01AG009740 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jessica Faul, KENNETH M LANGA · 1990 to 2026
$555.8M
Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Christopher K Laubenthal · 2000 to 2026
$70.0M
Creating a National Resource for Genetic Research in Behavioral & Health SciencesRC2AG036495 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WEIR, DAVID R. · 2009 to 2010
$7.4M
Expanding a National Resource for Genetic Research in Behavioral & Health ScienceRC4AG039029 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WEIR, DAVID R. · 2010 to 2010
$6.0M
NIA NIH HHS RC2 AG036495NIA NIH HHS RC4 AG039029NIA NIH HHS U01 AG009740
6 · The paper itself

Abstract

backgroundHaving longer lived parents has been shown to be an important predictor of health trajectories and life span. As such, parental life span is an important phenotype that may uncover genes that affect longevity.

methodsA genome-wide association study of parental life span in participants of European and African ancestry from the Health and Retirement Study was conducted.

resultsA genome-wide significant association was observed for rs35715456 (log10BF = 6.3) on chromosome 18 for the dichotomous trait of having at least one long-lived parent versus not having any long-lived parent. This association was not replicated in an independent sample from the InCHIANTI and Framingham Heart Study. The most significant association among single nucleotide polymorphisms in longevity candidate genes (APOE, MINIPP1, FOXO3, EBF1, CAMKIV, and OTOL1) was observed in the EBF1 gene region (rs17056207, p = .0002).

conclusionsA promising genetic signal for parental life span was identified but was not replicated in independent samples.

Indexed as

Genome-Wide Association StudyParentsAgedAged, 80 and overChromosomes, Human, Pair 18FemaleHumansLongevityMaleMiddle AgedPhenotypePolymorphism, Single NucleotideTrans-ActivatorsEBF1 protein, humanTrans-ActivatorsEpidemiologyGeneticsLife spanPublic healthSuccessful aging

Identifiers

PMID27816938
PMCPMC5861941
OpenAlexW2548218843

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.