ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2017
Contributors to Poor Mobility in Older Adults: Integrating White Matter Hyperintensities and Conditions Affecting Other Systems.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Gait and falls in cerebral small vessel disease: a systematic review and meta-analysis.Age and ageing · 2023Pooled it
- Serum-Derived Extracellular Vesicles as Biological Indicator of Mobility Resilience in Older Adults.Aging cell · 2026Article
- Locomotor savings relies on attentional control of walking in older, but not younger adults.bioRxiv : the preprint server for biology · 2026Article
- Association of intraindividual variability in simple reaction time with balance and falls in older cancer survivors: A secondary analysis.Journal of geriatric oncology · 2025Article
- Associations of Handgrip Strength and Testosterone With Cerebral White Matter Hyperintensity and Microstructural Injury.Journal of cachexia, sarcopenia and muscle · 2025Article
- An association of cognitive function with mobile metrics of community walking in older cancer survivors: A pilot study.Journal of geriatric oncology · 2025Article
- Article
- Neurodegenerative and Cerebrovascular Brain Pathologies Are Differentially Associated With Declining Grip Strength and Gait In Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- The relationship between clinical measures of cognitive function and grip strength in healthy older adults.BMC geriatrics · 2022Article
- Brain health correlates of mobility-related confidence.Experimental gerontology · 2022Observational
- Cortico-striatal functional connectivity and cerebral small vessel disease: Contribution to mild Parkinsonian signs.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2022Article
- Effects of a 5-Year Exercise Intervention on White Matter Microstructural Organization in Older Adults. A Generation 100 Substudy.Frontiers in aging neuroscience · 2022Article
- Resting state connectivity within the basal ganglia and gait speed in older adults with cerebral small vessel disease and locomotor risk factors.NeuroImage. Clinical · 2020Article
- Cognitive and motor correlates of grey and white matter pathology in Parkinson's disease.NeuroImage. Clinical · 2020Article
- Associations of Usual Pace and Complex Task Gait Speeds With Incident Mobility Disability.Journal of the American Geriatrics Society · 2019Article
- Complex Walking Tasks and Risk for Cognitive Decline in High Functioning Older Adults.Journal of Alzheimer's disease : JAD · 2019Article
- Predictors of gait speed and its change over three years in community-dwelling older people.Aging · 2018Article
- Article
- Walking speed decline in older adults is associated with elevated pro-BDNF in plasma extracellular vesicles.Experimental gerontology · 2017Article
- Neuropsychological impact of white matter hyperintensities in older adults without dementia.Applied neuropsychology. AdultArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundAge-related mobility limitations are debilitating and common. Cerebral white matter hyperintensities (WMH) and conditions affecting other systems are known contributors, but have been studied in isolation.
methodsIn 2,703 adults aged 65 years or older, we assessed cross-sectional and longitudinal gait speed and mobility disability (self-reported difficulty walking half mile) in those with and without high burden of MRI-defined WMH along with six other conditions (OCs) affecting mobility: gender-specific weak grip; poor self-reported vision; gender-specific lowest quartile of forced vital capacity; self-reported joint pain; ankle-arm index less than 0.9; and body mass index (BMI) greater than 30 kg/m2. Separate regression models adjusted for age, gender, and race were repeated for each OC and based on a 4-level predictor: -WMH/-OC; -WMH/+OC; +WMH/-OC; and +WMH/+OC.
resultsGait speed was fastest in those with -WMH/-OC and slowest for those with +WMH/+OC. Gait speed was similar for either WMH or one of the OC (p range: .07-.9), except for BMI. Those with a high BMI had slower gait speed than those with WMH (p = .01). Declines in gait speed over 6 years were similar for all groups. Results for both prevalent and incident mobility disability showed that associations for WMH and OC were similar for weak grip, poor vision, and low forced vital capacity (p range: .1-.7). Having joint pain, low ankle-arm index, or high BMI was associated with higher prevalent and incident mobility disability compared with having WMH (p range: <.001-.02).
conclusionsCerebral WMH should be considered along with conditions affecting mobility from other systems when considering risk and treatment for mobility limitations.
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What OpenQuestion holds
Registered trials
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