ArticleBrain and cognition2017
Adolescent neural response to reward is related to participant sex and task motivation.
Article in Brain and cognition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Evaluation of the Social Motivation Hypothesis of Autism: A Systematic Review and Meta-analysis.JAMA psychiatry · 2018Pooled it
- Contextualizing the adolescent social brain: Links to social health using data from the Adolescent Brain Cognitive Development Study.Developmental cognitive neuroscience · 2026Article
- Within-person imbalance of reward sensitivity and executive functioning across adolescent development: A longitudinal examination of the dual systems model from childhood to adulthood.Developmental psychology · 2025Article
- Distinct Topological Properties of the Reward Anticipation Network in Preadolescent Children With Binge Eating Disorder Symptoms.Journal of the American Academy of Child and Adolescent Psychiatry · 2024Article
- Sex-Specific Mechanisms Underlie Long-Term Potentiation at Hippocampus→Medium Spiny Neuron Synapses in the Medial Shell of the Nucleus Accumbens.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Article
- Sex differences in externalizing and internalizing traits and ventral striatal responses to monetary loss.Journal of psychiatric research · 2023Article
- Sex and pubertal influences on the neurodevelopmental underpinnings of schizophrenia: A case for longitudinal research on adolescents.Schizophrenia research · 2023Review
- Reward, motivation and brain imaging in human healthy participants - A narrative review.Frontiers in behavioral neuroscience · 2023Review
- Testosterone, oxytocin and co-operation: A hypothesis for the origin and function of music.Frontiers in psychology · 2023Article
- Altered Reward Processing and Sex Differences in Chronic Pain.Frontiers in neuroscience · 2022Article
- Baseline brain and behavioral factors distinguish adolescent substance initiators and non-initiators at follow-up.Frontiers in psychiatry · 2022Article
- The longitudinal stability of fMRI activation during reward processing in adolescents and young adults.NeuroImage · 2021Article
- Sex differences in neural responses to reward and the influences of individual reward and punishment sensitivity.BMC neuroscience · 2021Article
- Sex differences in the human reward system: convergent behavioral, autonomic and neural evidence.Social cognitive and affective neuroscience · 2020Article
- Adolescent gender differences in neural reactivity to a friend's positive affect and real-world positive experiences in social contexts.Developmental cognitive neuroscience · 2020Article
- Neural Responses to Reward in a Gambling Task: Sex Differences and Individual Variation in Reward-Driven Impulsivity.Cerebral cortex communications · 2020Article
- Neural systems underlying reward cue processing in early adolescence: The role of puberty and pubertal hormones.Psychoneuroendocrinology · 2019Article
- Could the link between drug addiction in adulthood and substance use in adolescence result from a blurring of the boundaries between incentive and hedonic processes?Substance abuse and rehabilitation · 2019Review
- Puberty and the human brain: Insights into adolescent development.Neuroscience and biobehavioral reviews · 2018Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Risky decision making is prominent during adolescence, perhaps contributed to by heightened sensation seeking and ongoing maturation of reward and dopamine systems in the brain, which are, in part, modulated by sex hormones. In this study, we examined sex differences in the neural substrates of reward sensitivity during a risky decision-making task and hypothesized that compared with girls, boys would show heightened brain activation in reward-relevant regions, particularly the nucleus accumbens, during reward receipt. Further, we hypothesized that testosterone and estradiol levels would mediate this sex difference. Moreover, we predicted boys would make more risky choices on the task. While boys showed increased nucleus accumbens blood oxygen level-dependent (BOLD) response relative to girls, sex hormones did not mediate this effect. As predicted, boys made a higher percentage of risky decisions during the task. Interestingly, boys also self-reported more motivation to perform well and earn money on the task, while girls self-reported higher state anxiety prior to the scan session. Motivation to earn money partially mediated the effect of sex on nucleus accumbens activity during reward. Previous research shows that increased motivation and salience of reinforcers is linked with more robust striatal BOLD response, therefore psychosocial factors, in addition to sex, may play an important role in reward sensitivity. Elucidating neurobiological mechanisms that support adolescent sex differences in risky decision making has important implications for understanding individual differences that lead to advantageous and adverse behaviors that affect health outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.