ArticleBiomaterials2017
Diamagnetic chemical exchange saturation transfer (diaCEST) affords magnetic resonance imaging of extracellular matrix hydrogel implantation in a rat model of stroke.
Article in Biomaterials, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- Translational Considerations for Injectable Biomaterials and Bioscaffolds to Repair and Regenerate Brain Tissue.Advanced healthcare materials · 2026Review
- Hydrogel-based biomaterials for brain regeneration after stroke: Gap to clinical translation.Biomaterials translational · 2025Review
- Design Chemical Exchange Saturation Transfer Contrast Agents and Nanocarriers for Imaging Proton ExchangeACS nano · 2024Review
- Advancements and Challenges in Hydrogel Engineering for Regenerative Medicine.Gels (Basel, Switzerland) · 2024Review
- A Promising Application of Injectable Hydrogels in Nerve Repair and Regeneration for Ischemic Stroke.International journal of nanomedicine · 2024Review
- Post-Stroke Timing of ECM Hydrogel Implantation Affects Biodegradation and Tissue Restoration.International journal of molecular sciences · 2021Article
- Detecting and Monitoring Hydrogels with Medical Imaging.ACS biomaterials science & engineering · 2021Review
- Development of intravoxel inhomogeneity correction for chemical exchange saturation transfer spectral imaging: a high-resolution field map-based deconvolution algorithm for magnetic field inhomogeneity correction.Magnetic resonance in medicine · 2020Article
- CEST MRI detectable liposomal hydrogels for multiparametric monitoring in the brain at 3T.Theranostics · 2020Article
- Chemical exchange saturation transfer magnetic resonance imaging and its main and potential applications in pre-clinical and clinical studies.Quantitative imaging in medicine and surgery · 2019Review
- Article
- A roadmap for promoting endogenous in situ tissue restoration using inductive bioscaffolds after acute brain injury.Brain research bulletin · 2019Review
- Hydrogel Scaffolds: Towards Restitution of Ischemic Stroke-Injured Brain.Translational stroke research · 2019Review
- Bioscaffold-Induced Brain Tissue Regeneration.Frontiers in neuroscience · 2019Review
- Biodegradation of ECM hydrogel promotes endogenous brain tissue restoration in a rat model of stroke.Acta biomaterialia · 2018Article
- Hydrogel-based scaffolds to support intrathecal stem cell transplantation as a gateway to the spinal cord: clinical needs, biomaterials, and imaging technologies.NPJ Regenerative medicine · 2018Review
- Non-invasive monitoring ofTheranostics · 2018Article
- Long-term retention of ECM hydrogel after implantation into a sub-acute stroke cavity reduces lesion volume.Acta biomaterialia · 2017Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Extracellular matrix (ECM) is widely used as an inductive biological scaffold to repair soft tissue after injury by promoting functional site-appropriate remodeling of the implanted material. However, there is a lack of non-invasive analysis methods to monitor the remodeling characteristics of the ECM material after implantation and its biodegradation over time. We describe the use of diamagnetic chemical exchange saturation transfer (CEST) magnetic resonance imaging to monitor the distribution of an ECM hydrogel after intracerebral implantation into a stroke cavity. In vitro imaging indicated a robust concentration-dependent detection of the ECM precursor and hydrogel at 1.8 and 3.6 ppm, which broadly corresponded to chondroitin sulfate and fibronectin. This detection was robust to changes in pH and improved at 37 °C. In vivo implantation of ECM hydrogel into the stroke cavity in a rat model corresponded macroscopically to the distribution of biomaterial as indicated by histology, but mismatches were also evident. Indeed, CEST imaging detected an endogenous "increased deposition". To account for this endogenous activity, pre-implantation images were subtracted from post-implantation images to yield a selective visualization of hydrogel distribution in the stroke cavity and its evolution over 7 days. The CEST detection of ECM returned to baseline within 3 days due to a decrease in fibronectin and chondroitin sulfate in the hydrogel. The distribution of ECM hydrogel within the stroke cavity is hence feasible in vivo, but further advances are required to warrant a selective long-term monitoring in the context of biodegradation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.