Evidence map›Paper›PMID 27815804›Full record

ArticlePurinergic signalling2017

Lung injury during LPS-induced inflammation occurs independently of the receptor P2Y

Elisabetta Liverani

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Purinergic signalling, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Mediators of inflammation · 2026
    Article
  2. Article
  3. Lentinan and β-glucan extract from shiitake mushroom,Iranian journal of basic medical sciences · 2023
    Article
  4. P2 Purinergic Signaling in the Distal Lung in Health and Disease.International journal of molecular sciences · 2020
    Review
  5. Article
  6. Purinergic Signalling: Therapeutic Developments.Frontiers in pharmacology · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Elisabetta LiveraniSol Sherry Thrombosis Research Center and Center for Inflammation, Translational and Clinical Lung Research, Temple University School of Medicine, Temple University Hospital, Temple University, 3420 N. Broad Street, Philadelphia, PA, 19140, USA. eliliverani@temple.edu.
Temple University Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Disruption of the lung endothelial and epithelial barriers during acute inflammation leads to excessive neutrophil migration. It is likely that activated platelets promote pulmonary recruitment of neutrophils during inflammation, and previous studies have found that anti-platelet therapy and depletion of circulating platelets have lung-protective effects in different models of inflammation. Because ADP signaling is important for platelet activation, I investigated the role of the ADP-receptor P2Y

Indexed as

AnimalsBlood PlateletsInflammationLeukocytesLipopolysaccharidesLung InjuryMiceMice, KnockoutReceptors, Purinergic P2Y1LipopolysaccharidesReceptors, Purinergic P2Y1InflammationLungP2Y1 receptorPlatelets

Identifiers

PMID27815804
PMCPMC5334203
OpenAlexW2547521865

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.