Evidence map›Paper›PMID 27815773›Full record

ArticleBrain imaging and behavior2017

The neural correlates of priming emotion and reward systems for conflict processing in alcoholics.

T Schulte, Y-C Jung, E V Sullivan, A Pfefferbaum, M Serventi, E M Müller-Oehring

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain imaging and behavior, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

T SchulteNeuroscience Program, Biosciences Division, SRI International, Menlo Park, CA, 94025-3493, USA. til@stanford.edu.
Y-C JungDeptartment of Psychiatry & Beh. Sci, Stanford University, Stanford, CA, USA.
E V SullivanDeptartment of Psychiatry & Beh. Sci, Stanford University, Stanford, CA, USA.
A PfefferbaumNeuroscience Program, Biosciences Division, SRI International, Menlo Park, CA, 94025-3493, USA.
M ServentiNeuroscience Program, Biosciences Division, SRI International, Menlo Park, CA, 94025-3493, USA.
E M Müller-OehringNeuroscience Program, Biosciences Division, SRI International, Menlo Park, CA, 94025-3493, USA.
SRI International · USStanford University · US

Funding

NEUROIMAGING OF CONNECTIVITY IN ALCOHOLISMR01AA012388 · NIAAA · SRI INTERNATIONAL · PI PFEFFERBAUM, ADOLF, SULLIVAN, EDITH VIONI · 2000 to 2015
$10.6M
Neurodegeneration and Brain Function in Aging with HIV and Parkinson's DiseaseR01AA023165 · NIAAA · SRI INTERNATIONAL · PI SCHULTE, TILMAN · 2014 to 2017
$3.0M
US-France Research Collaboration on Neuroimaging Studies of AlcoholismU01AA017923 · NIAAA · STANFORD UNIVERSITY · PI PFEFFERBAUM, ADOLF, SULLIVAN, EDITH VIONI · 2008 to 2017
$2.4M
Translational Studies of Brain Circuitry Disrupted by AlcoholismK05AA017168 · NIAAA · STANFORD UNIVERSITY · PI SULLIVAN, EDITH VIONI · 2008 to 2017
$2.2M
Neural Correlates of Implicit Processes of Attention & Emotion in AlcoholismR01AA018022 · NIAAA · SRI INTERNATIONAL · PI SCHULTE, TILMAN · 2008 to 2012
$2.1M
International Research Collaboration on Neuroimaging Studies of AlcoholismR01AA017923 · NIAAA · STANFORD UNIVERSITY · PI PFEFFERBAUM, ADOLF, SULLIVAN, EDITH VIONI · 2018 to 2019
$496k
NIAAA NIH HHS AA012388NIAAA NIH HHS AA017168NIAAA NIH HHS AA017923NIAAA NIH HHS AA018022NIAAA NIH HHS AA023165NIAAA NIH HHS K05 AA017168NIAAA NIH HHS R01 AA012388NIAAA NIH HHS R01 AA017923NIAAA NIH HHS R01 AA018022NIAAA NIH HHS R01 AA023165NIAAA NIH HHS U01 AA017923
6 · The paper itself

Abstract

Emotional dysregulation in alcoholism (ALC) may result from disturbed inhibitory mechanisms. We therefore tested emotion and alcohol cue reactivity and inhibitory processes using negative priming. To test the neural correlates of cue reactivity and negative priming, 26 ALC and 26 age-matched controls underwent functional MRI performing a Stroop color match-to-sample task. In cue reactivity trials, task-irrelevant emotion and alcohol-related pictures were interspersed between color samples and color words. In negative priming trials, pictures primed the semantic content of an alcohol or emotion Stroop word. Behaviorally, both groups showed response facilitation to picture cue trials and response inhibition to primed trials. For cue reactivity to emotion and alcohol pictures, ALC showed midbrain-limbic activation. By contrast, controls activated frontoparietal executive control regions. Greater midbrain-hippocampal activation in ALC correlated with higher amounts of lifetime alcohol consumption and higher anxiety. With negative priming, ALC exhibited frontal cortical but not midbrain-hippocampal activation, similar to the pattern observed in controls. Higher frontal activation to alcohol-priming correlated with less craving and to emotion-priming with fewer depressive symptoms. The findings suggest that neurofunctional systems in ALC can be primed to deal with upcoming emotion- and alcohol-related conflict and can overcome the prepotent midbrain-limbic cue reactivity response.

Indexed as

RewardAdultAgedAlcoholismBrainBrain MappingConflict, PsychologicalCuesEmotionsExecutive FunctionFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedReaction TimeAlcohol and emotionCue reactivityExecutive controlFunctional MRIMidbrain-limbicPriming

Identifiers

PMID27815773
PMCPMC5418124
OpenAlexW2548358208

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.