ArticleBreast cancer research and treatment2017
A model for individualized risk prediction of contralateral breast cancer.
Article in Breast cancer research and treatment, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- A systematic review of prediction models for risk of breast cancer.BMC cancer · 2025Pooled it
- Genetic Testing for All Breast Cancer Patients: The GET FACTS Randomized Clinical Trial.JAMA network open · 2026Trial
- The association of mammographic density with risk of contralateral breast cancer and change in density with treatment in the WECARE study.Breast cancer research : BCR · 2018Trial
- A Bayesian Learning Model for Joint Risk Prediction of Alcohol and Cannabis Use Disorders.Statistics in medicine · 2026Article
- CBCRisk-Mastectomy: A Risk Prediction Tool to Aid Contralateral Prophylactic Mastectomy Decision Making.medRxiv : the preprint server for health sciences · 2026Article
- Can DNA Methylation in Peritumoral and Contralateral Breast Tissue Predict Recurrence or Second Breast Cancers?Current issues in molecular biology · 2026Article
- A scoping review of web-based, interactive, personalized decision-making tools available to support breast cancer treatment and survivorship care.Journal of cancer survivorship : research and practice · 2025Article
- Society of Surgical Oncology Breast Disease Site Working Group Statement on Contralateral Mastectomy: Indications, Outcomes, and Risks.Annals of surgical oncology · 2024Review
- Contralateral prophylactic mastectomy for unilateral breast cancer in Chinese female population: a retrospective cohort study.Gland surgery · 2023Article
- Trends in Radiation Dose to the Contralateral Breast During Breast Cancer Radiation Therapy.Radiation research · 2023Article
- EBCC-13 manifesto: Balancing pros and cons for contralateral prophylactic mastectomy.European journal of cancer (Oxford, England : 1990) · 2023Review
- The Contribution of Germline Pathogenic Variants in Breast Cancer Genes to Contralateral Breast Cancer Risk inCancers · 2023Article
- Tools for Contralateral Prophylactic Mastectomy Decision Making.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2022Article
- Prediction Models and Decision Aids for Women with Ductal Carcinoma In Situ: A Systematic Literature Review.Cancers · 2022Review
- CBCRisk-Black: a personalized contralateral breast cancer risk prediction model for black women.Breast cancer research and treatment · 2022Article
- Clinicopathological features and prognosis of bilateral breast cancer: a single-center cohort study based on Chinese data.Annals of translational medicine · 2022Article
- Is there an increasing trend of risk-reducing prophylactic mastectomy procedure in preventing breast cancer among women?Turkish journal of surgery · 2021Article
- A preliminary risk prediction model for cannabis use disorder.Preventive medicine reports · 2020Article
- Clinical characteristics and the associated risk factors of the development of bilateral breast cancers: A case-control study.Annals of medicine and surgery (2012) · 2020Article
- Contralateral breast cancer risk in patients with ductal carcinoma in situ and invasive breast cancer.NPJ breast cancer · 2020Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
purposePatients diagnosed with invasive breast cancer (BC) or ductal carcinoma in situ are increasingly choosing to undergo contralateral prophylactic mastectomy (CPM) to reduce their risk of contralateral BC (CBC). This is a particularly disturbing trend as a large proportion of these CPMs are believed to be medically unnecessary. Many BC patients tend to substantially overestimate their CBC risk. Thus, there is a pressing need to educate patients effectively on their CBC risk. We develop a CBC risk prediction model to aid physicians in this task.
methodsWe used data from two sources: Breast Cancer Surveillance Consortium and Surveillance, Epidemiology, and End Results to build the model. The model building steps are similar to those used in developing the BC risk assessment tool (popularly known as Gail model) for counseling women on their BC risk. Our model, named CBCRisk, is exclusively designed for counseling women diagnosed with unilateral BC on the risk of developing CBC.
resultsWe identified eight factors to be significantly associated with CBC-age at first BC diagnosis, anti-estrogen therapy, family history of BC, high-risk pre-neoplasia status, estrogen receptor status, breast density, type of first BC, and age at first birth. Combining the relative risk estimates with the relevant hazard rates, CBCRisk projects absolute risk of developing CBC over a given period.
conclusionsBy providing individualized CBC risk estimates, CBCRisk may help in counseling of BC patients. In turn, this may potentially help alleviate the rate of medically unnecessary CPMs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.