ReviewLangenbeck's archives of surgery2017
Stage-directed therapy of pleural empyema.
Review in Langenbeck's archives of surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 58 citations in OpenAlex.
- Comparing the efficacy of video assisted thoracoscopic surgery (VATS) vs intrapleural fibrinolytic therapy in children with pleural empyema.Pediatric surgery international · 2025Trial
- Early source control with non-intubated uniportal video-assisted thoracoscopic surgery for acute thoracic empyema: a retrospective pilot cohort study.Journal of thoracic disease · 2026Article
- Focus on pleural empyema: etiology, epidemiology, infectiology, treatment, and impact of the COVID-19 pandemic-a single-center analysis.Journal of thoracic disease · 2026Article
- Surgical interventions for pleural infection.Breathe (Sheffield, England) · 2025Review
- Outcomes of adult empyema thoracis cases managed in a tertiary hospital in Uganda: a retrospective cohort study.BMC pulmonary medicine · 2025Article
- Pleural Empyema in Spain (2016-2022): A Nationwide Study on Trends in Hospitalizations, Mortality, and Impact of Comorbidities.Journal of personalized medicine · 2025Article
- Risk factors and prognostic predictors of recurrent bacterial empyema in patients after surgical treatment.BMC infectious diseases · 2025Article
- Role of RAPID score and surgery in the management of pleural infection: a single center retrospective study.Journal of thoracic disease · 2023Article
- Open decortication for patients presenting with stage III tuberculous empyema with low density lines on CT imaging.Scientific reports · 2023Article
- Targeting the PAI-1 Mechanism with a Small Peptide Increases the Efficacy of Alteplase in a Rabbit Model of Chronic Empyema.Pharmaceutics · 2023Article
- Pleural empyema secondary to perforated diverticulosis due to biliary neoplasia infiltration.BMJ case reports · 2023Article
- Empyema after image-guided percutaneous intercostal drainage of subdiaphragmatic collection: a case series.Journal of thoracic disease · 2022Article
- Two years later: Is the SARS-CoV-2 pandemic still having an impact on emergency surgery? An international cross-sectional survey among WSES members.World journal of emergency surgery : WJES · 2022Article
- Efficacy of video-assisted thoracoscopic surgery versus intrapleural streptokinase for treatment of parapneumonic empyema with multiloculation and septation.Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery · 2022Article
- Nanomedicine to fight infectious disease.Advanced drug delivery reviews · 2021Review
- Retrospective case-control study on the outcomes of early minimally invasive pleural lavage for pleural empyema in oncology patients.Thoracic cancer · 2021Article
- Pleural empyema secondary to nephropleural fistula in complicated pyonephrosis.Radiology case reports · 2021Article
- From Bedside to the Bench-A Call for Novel Approaches to Prognostic Evaluation and Treatment of Empyema.Frontiers in pharmacology · 2021Review
- Uniportal Thoracoscopic Debridement for Children With Refractory Pleural Empyema: Case Series of 21 Patients.Frontiers in pediatrics · 2021Article
- Multimodal treatment for acute empyema based on the patient's condition, including patients who are bedridden: A single center retrospective study.Canadian journal of respiratory therapy : CJRT = Revue canadienne de la therapie respiratoire : RCTR · 2021Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIntensivists and surgeons are often confronted with critically ill patients suffering from pleural empyema. Due to it' s multifactorial pathogenesis and etiology, medicals should be sensitized to recognize the different stages of the disease. Besides a whole bundle of different established classification systems, the progress of pleural effusions can be subdivided into the early exudative, the intermediate fibropurulent and the late organized phase according to the classification of the American Thoracic Society.
resultsRapid diagnosis of pleura empyema is essential for patients' survival. Due to the importance of stage-adapted therapeutic decisions, different classification systems were established. Depending on the stage of pleural empyema, both antimicrobial and interventional approaches are indicated. For organized empyema, minimally invasive and open thoracic surgery are gold standard. Surgery is based on the three therapeutic columns: removal of pleural fluid, debridement and decortication. In general, therapy must be intended stage-directed following multidisciplinary concepts including surgeons, intensivists, anesthesiologists, physiotherapists and antibiotic stewards. Despite an established therapeutic algorithm is presented in this review, there is still a lack of randomized, prospective studies to evaluate potential benefits of minimally invasive (versus open) surgery for end-stage empyema or of catheter-directed intrathoracic fibrinolysis (versus minimally invasive surgery) for intermediate-stage pleural empyema. Any delay in adequate therapy results in an increased morbidity and mortality.
conclusionThe aim of this article is to review current treatment standards for different phases of adult thoracic empyema from an interdisciplinary point of view.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.