Trial reportInternational journal of colorectal disease2017
Comparison of inflammatory responses following robotic and open colorectal surgery: a prospective study.
Trial report in International journal of colorectal disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 3 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- A systematic review and meta-analysis of the comparative effectiveness and short-term outcomes of the KangDuo and da Vinci robotic platforms in colorectal cancer surgery.Journal of robotic surgery · 2025Pooled it
- A systematic review on biomarkers implemented to measure surgical stress response in patients undergoing colorectal surgery.International journal of colorectal disease · 2025Pooled it
- Postoperative inflammatory response in colorectal cancer surgery: a meta-analysis.International journal of colorectal disease · 2023Pooled it
- Open versus robotic-assisted repair of midline ventral hernias with defect width 2-8 cm - a randomized clinical trial (OVER).Hernia : the journal of hernias and abdominal wall surgery · 2026Trial
- Short-term outcomes of KangDuo surgical robot- versus Da Vinci surgical robot-assisted radical resection of colorectal cancer: a prospective cohort study.BMC surgery · 2025Trial
- The perioperative dynamics of IL-7 following robot-assisted and open colorectal surgery.Scientific reports · 2018Trial
- Minimally invasive colectomy May contribute to a better long-term prognosis for patients when a textbook outcome is not achieved.Surgery today · 2026Article
- Robotic liver surgery: enhancing immune competence and minimizing postsurgical inflammation.Surgical endoscopy · 2025Article
- Review
- Comparative clinical efficacy of three surgical modalities for the treatment of malignant tumours of the left hemicolon.World journal of gastrointestinal surgery · 2025Article
- Robot-Assisted Colorectal Cancer Surgery Mitigates Early Postoperative Immunosuppression and Angiogenesis.International journal of molecular sciences · 2025Article
- PD-1 Blockade Mitigates Surgery-Induced Immunosuppression and Increases the Efficacy of Photodynamic Therapy for Pleural Mesothelioma.Cancer research communications · 2025Article
- Robotics versus open surgery: the impact on cytokine release and patient outcomes.Journal of robotic surgery · 2025Review
- A Narrative Review on the Role of Artificial Intelligence (AI) in Colorectal Cancer Management.Cureus · 2025Review
- Harnessing Artificial Intelligence for the Detection and Management of Colorectal Cancer Treatment.Cancer prevention research (Philadelphia, Pa.) · 2024Review
- Robotic-assisted surgery for left-sided colon and rectal resections is associated with reduction in the postoperative surgical stress response and improved short-term outcomes: a cohort study.Surgical endoscopy · 2024Article
- Comparison of tissue damage and inflammation for robotic laparoscopy and conventional laparoscopy in early endometrial cancer.Frontiers in medicine · 2024Article
- Article
- Laparoscopic-Assisted Colorectal Resection Can Reduce the Inhibition of Immune Function Compared with Conventional Open Surgery: A Retrospective Clinical Study.Journal of clinical medicine · 2023Article
- Impact of severe postoperative inflammatory response on recurrence after curative resection of colorectal cancer.International journal of colorectal disease · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeRobotic colorectal surgery continues to rise in popularity, but there remains little evidence on the stress response following the procedure. The aim of this study was to evaluate the inflammatory response to robotic colorectal surgery and compare it with the response generated by open colorectal surgery.
methodsThis was a prospective nonrandomized comparative study involving 61 patients with colorectal cancer. The evaluation of inflammatory response to either robotic or open colorectal surgery was expressed as changes in interleukin-1β, interleukin-1 receptor antagonist, interleukin-6, tumor necrosis factor-α, C-reactive protein, and procalcitonin during the first three postoperative days.
resultsOf the 61 patients, 33 underwent robotic colorectal surgery while 28 had open colorectal surgery. Groups were comparable with respect to age, sex, BMI, cancer stage, and type of resection. The relative increase of interleukin-1 receptor antagonist at 8 h postoperative, compared to baseline, was higher in the open group (P = 0.006). The decrease of interleukin-1 receptor antagonist on postoperative days 1 and 3, compared to the maximum at 8 h, was more pronounced in the open group than in the robotic group (P = 0.008, P = 0.006, respectively), and the relative increase of interleukin-6 at 8 h after incision was higher in the open group (P = 0.007). The relative increase of procalcitonin on postoperative days 1 and 3 was higher in the open group than the robotic group (P < 0.001, P = 0.004, respectively).
conclusionsThis study shows that when compared with open colorectal surgery, robotic colorectal surgery results in a less pronounced inflammatory response and more pronounced anti-inflammatory action.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.