Evidence map›Paper›PMID 27815653›Full record

SynthesisClinical rheumatology2017

Relationship of HLA-B*51 and HLA-B*52 alleles and TNF-α-308A/G polymorphism with susceptibility to Takayasu arteritis: a meta-analysis.

Si Chen, Haixia Luan, Liubing Li, Xiaoli Zeng, Tian Wang, Yongzhe Li, Hui Yuan

Abstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Clinical rheumatology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Takayasu's disease effects on the kidneys: current perspectives.International journal of nephrology and renovascular disease · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Si ChenDepartment of Clinical Laboratory, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Haixia LuanDepartment of Clinical Laboratory, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Liubing LiDepartment of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.
Xiaoli ZengDepartment of Clinical Laboratory, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Tian WangDepartment of Clinical Laboratory, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Yongzhe LiDepartment of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China. yongzhelipumch@126.com.
Hui YuanDepartment of Clinical Laboratory, Beijing Anzhen Hospital, Capital Medical University, Beijing, China. 18911662931@189.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We performed a meta-analysis to determine whether combined evidence shows an association between HLA-B*51 and HLA-B*52 alleles and TNF-α-308A/G polymorphism and the susceptibility to Takayasu arteritis (TA). Relevant articles dated November 2015 were acquired from the PubMed, Embase and Cochrane databases. The number of genotypes and/or alleles for HLA-B*51 and HLA-B*52 alleles and TNF-α-308 A/G polymorphism in cases and control subjects was extracted, and statistical analysis was conducted using STATA 11.2 software. We included 20 studies with 1864 TA patients and 6973 controls. The HLA-B*52 allele was found to be associated with TA (pooled OR 3.91, 95 % CI 3.22-4.74, P < 0.0001). The meta-analysis of TNF-α-308 A/G polymorphism for the A allele vs. G allele (P = 0.006) and AA + AG vs. GG (P = 0.023) revealed a significant association with TA. However, we did not find that the HLA-B*51 allele was associated with TA. This meta-analysis demonstrated that the HLA-B*52 allele and TNF-α-308 A/G polymorphism may contribute to TA susceptibility.

Indexed as

Polymorphism, GeneticAllelesCase-Control StudiesGenetic Predisposition to DiseaseGenotypeHLA-B51 AntigenHLA-B52 AntigenHumansInflammationSensitivity and SpecificityTakayasu ArteritisTumor Necrosis Factor-alphaHLA-B51 AntigenHLA-B52 AntigenTNF protein, humanTumor Necrosis Factor-alphaHLAMeta-analysisPolymorphismTakayasu arteritisTNF-α

Identifiers

PMID27815653

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.