ArticlePediatric surgery international2016
Formula feeding and systemic hypoxia synergistically induce intestinal hypoxia in experimental necrotizing enterocolitis.
Article in Pediatric surgery international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06319326 (Intestinal Perfusion After Feeding in Preterm and Term Infants), which is not on this map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Intestinal Perfusion After Feeding in Preterm and Term Infants
Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Remote ischaemic conditioning in necrotising enterocolitis: a phase I feasibility and safety study.Archives of disease in childhood. Fetal and neonatal edition · 2023Trial
- Local Peritoneal Cytokine Response IL-1β, IL-6, TNF-α in a Standardized Neonatal Rat Model of Necrotizing Enterocolitis.International journal of molecular sciences · 2026Article
- Inhibition of CHI3L1 attenuates excessive autophagy in intestinal epithelial cells to reduce the severity of necrotizing enterocolitis.Cell death discovery · 2025Article
- Parthanatos initiated by ROS-induced DNA damage is involved in intestinal epithelial injury during necrotizing enterocolitis.Cell death discovery · 2024Article
- Transfusion-associated necrotising enterocolitis in very low birth weight babies: transfusion and feeding practices in two neonatal units in Bloemfontein, Free State.The Southern African journal of critical care : the official journal of the Critical Care Society · 2024Article
- Necrotizing enterocolitis: recent advances in treatment with translational potential.Pediatric surgery international · 2023Review
- A potential pathogenic hypoxia-related gene HK2 in necrotizing enterocolitis (NEC) of newborns.BMC pediatrics · 2022Article
- Remote ischemic conditioning causes CD4 T cells shift towards reduced cell-mediated inflammation.Pediatric surgery international · 2022Article
- Remote ischemic conditioning in necrotizing enterocolitis: study protocol of a multi-center phase II feasibility randomized controlled trial.Pediatric surgery international · 2022Article
- Fingolimod protects against experimental necrotizing enterocolitis by regulating intestinal T cell differentiation.Translational pediatrics · 2022Article
- Exosome-Derived MicroRNAs of Human Milk and Their Effects on Infant Health and Development.Biomolecules · 2021Review
- Hydrogen Promotes the M1 Macrophage Conversion During the Polarization of Macrophages in Necrotizing Enterocolitis.Frontiers in pediatrics · 2021Article
- Remote ischemic conditioning counteracts the intestinal damage of necrotizing enterocolitis by improving intestinal microcirculation.Nature communications · 2020Article
- Transfusion-related Gut Injury and Necrotizing Enterocolitis.Clinics in perinatology · 2020Review
- Formula feeding and immature gut microcirculation promote intestinal hypoxia, leading to necrotizing enterocolitis.Disease models & mechanisms · 2019Article
- Endothelin receptor B affects the perfusion of newborn intestine: possible mechanism of necrotizing enterocolitis development.Pediatric surgery international · 2019Article
- Hydrogen Sulfide Donor GYY4137 Acts Through Endothelial Nitric Oxide to Protect Intestine in Murine Models of Necrotizing Enterocolitis and Intestinal Ischemia.The Journal of surgical research · 2019Article
- Recent advances in understanding necrotizing enterocolitis.F1000Research · 2019Review
- Influence of stress factors on intestinal epithelial injury and regeneration.Pediatric surgery international · 2018Article
- Inhibition of corticotropin-releasing hormone receptor 1 and activation of receptor 2 protect against colonic injury and promote epithelium repair.Scientific reports · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeFeeding and systemic hypoxia are major stresses inducing necrotizing enterocolitis (NEC). This study aims to investigate the role of systemic hypoxia in NEC and its effect before and after feeding.
methodsNeonatal mice were studied in three groups. Control (N = 9): breast feeding; NEC A (N = 8), gavage feeding + lipopolysaccharide (LPS) + preprandial hypoxia; and NEC B (N = 9), feeding + LPS + postprandial hypoxia. Pimonidazole, a hypoxia marker, was injected intraperitoneally before ileum was harvested for histology and quantitative RT-PCR studies. Statistical analysis was done using the ANOVA and Chi-square test.
resultsNEC incidence was 62.5% in NEC A and 88.9% in NEC B. The mortality in NEC B (55.6%) but not A (25%) is significantly higher than control (0%, p < 0.05). Pimonidazole staining elevated in both NEC A and B with higher pimonidazole grade in NEC B (p < 0.01). Both NEC groups had increased the expression of hypoxia-related genes: HIF-1α, GLUT-1, and PHD-3 with GLUT-1 expressed more in NEC B compared with NEC A (p < 0.01). The inflammation marker, IL6, was similarly raised in both NEC A and B.
conclusionFeeding and postprandial hypoxia synergistically induce intestinal hypoxia in NEC. As feeding increases intestinal oxygen demand, maintaining a balance between intestinal oxygen supply and demand is important to prevent NEC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.