Evidence map›Paper›PMID 27815504›Full record

ArticleThe Journal of biological chemistry2016

The Arrhythmogenic Calmodulin Mutation D129G Dysregulates Cell Growth, Calmodulin-dependent Kinase II Activity, and Cardiac Function in Zebrafish.

Martin W Berchtold, Triantafyllos Zacharias, Katarzyna Kulej, Kevin Wang, Raffaela Torggler, Thomas Jespersen, Jau-Nian Chen, Martin R Larsen, Jonas M la Cour

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.1field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Calmodulin Mutations Associated with Heart Arrhythmia: A Status Report.International journal of molecular sciences · 2020
    Review
  10. Article
  11. Review
  12. Human Calmodulin Mutations.Frontiers in molecular neuroscience · 2018
    Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 4 countries.

Martin W BerchtoldFrom the Department of Biology and mabe@bio.ku.dk.ORCID http://orcid.org/0000-0001-8995-9047
Triantafyllos ZachariasFrom the Department of Biology and.
Katarzyna Kulejthe Department of Biochemistry and Molecular Biology, University of Southern Denmark, 5230 Odense, Denmark, and.
Kevin Wangthe Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, California 90095.
Raffaela TorgglerFrom the Department of Biology and.
Thomas Jespersenthe Danish Arrhythmia Research Centre, University of Copenhagen, 2100 Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-6575-360X
Jau-Nian Chenthe Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, California 90095.ORCID http://orcid.org/0000-0001-8807-3607
Martin R Larsenthe Department of Biochemistry and Molecular Biology, University of Southern Denmark, 5230 Odense, Denmark, and.ORCID http://orcid.org/0000-0001-6203-0123
Jonas M la CourFrom the Department of Biology and jonas@bio.ku.dk.
University of California, Los Angeles · USUniversity of Southern Denmark · DKBio-Medical Science (South Korea) · KRUniversity of Copenhagen · DKUniversity of Jos · NG

Funding

Elucidating the molecular mechanisms regulating embryonic cardiac rhythmicityR01HL096980 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHEN, JAU-NIAN · 2010 to 2013
$1.5M
NHLBI NIH HHS R01 HL096980
6 · The paper itself

Abstract

Calmodulin (CaM) is a Ca

Indexed as

AnimalsArrhythmias, CardiacCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2CalmodulinCell ProliferationCells, CulturedHumansLong QT SyndromeMutationMyocytes, CardiacPhosphorylationProtein ConformationTachycardia, VentricularZebrafishCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2CalmodulinCa2+/calmodulin-dependent protein kinase II (CaMKII)calciumcalmodulin (CaM)catecholaminergic polymorphic ventricular tachycardia (CPVT)cell signalingDT40heart failure

Identifiers

PMID27815504
PMCPMC5207174
OpenAlexW2547562734

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.