Evidence map›Paper›PMID 27815446›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2016

Blood Stem Cell Activity Is Arrested by Th1-Mediated Injury Preventing Engraftment following Nonmyeloablative Conditioning.

Antonia M S Müller, Mareike Florek, Holbrook E K Kohrt, Natascha J Küpper, Alexander Filatenkov, Jessica A Linderman, Husein Hadeiba, Robert S Negrin, Judith A Shizuru

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Antonia M S MüllerDivision of Blood and Marrow Transplantation, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305; anmuelle@stanford.edu jshizuru@stanford.edu.
Mareike FlorekDivision of Blood and Marrow Transplantation, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0001-6049-3482
Holbrook E K KohrtDivision of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305.
Natascha J KüpperDivision of Blood and Marrow Transplantation, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305.
Alexander FilatenkovDivision of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305; and.ORCID 0000-0002-5165-4173
Jessica A LindermanDivision of Blood and Marrow Transplantation, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305.
Husein HadeibaLaboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0002-2491-1365
Robert S NegrinDivision of Blood and Marrow Transplantation, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305.
Judith A ShizuruDivision of Blood and Marrow Transplantation, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305; anmuelle@stanford.edu jshizuru@stanford.edu.
Stanford University · USUniversity Hospital of Zurich · CH

Funding

TLI/ATG CONDTIONING: KIDNEY/BLOOD STEM CELL TRANSPLANTSP01HL075462 · NHLBI · STANFORD UNIVERSITY · PI ENGLEMAN, EDGAR G. · 2004 to 2020
$27.9M
The Role of Thymic Homing Dendritic Cells in Oral ToleranceR01AI109452 · NIAID · PALO ALTO VETERANS INSTIT FOR RESEARCH · PI HADEIBA, HUSEIN · 2014 to 2018
$1.8M
Barriers to Allogeneic Hematopoietic Stem Cell EngraftmentR01HL087240 · NHLBI · STANFORD UNIVERSITY · PI SHIZURU, JUDITH ANNE · 2007 to 2010
$1.5M
NHLBI NIH HHS P01 HL075462NHLBI NIH HHS R01 HL087240NIAID NIH HHS R01 AI109452
6 · The paper itself

Abstract

T cells are widely used to promote engraftment of hematopoietic stem cells (HSCs) during an allogeneic hematopoietic cell transplantation. Their role in overcoming barriers to HSC engraftment is thought to be particularly critical when patients receive reduced doses of preparative chemotherapy and/or radiation compared with standard transplantations. In this study, we sought to delineate the effects CD4

Indexed as

Transplantation ConditioningAnimalsBone Marrow TransplantationCD4-Positive T-LymphocytesCell CycleGraft SurvivalHematopoiesisHematopoietic Stem CellsHematopoietic Stem Cell TransplantationInterferon-gammaInterleukin-12MiceMice, Inbred C57BLPeripheral Blood Stem CellsTh1 CellsTissue DonorsInterferon-gammaInterleukin-12

Identifiers

PMID27815446
PMCPMC5096509
OpenAlexW2530837876

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.