Evidence map›Paper›PMID 27815443›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2016

Human B-1 and B-2 B Cells Develop from Lin-CD34+CD38lo Stem Cells.

Tâm D Quách, Thomas J Hopkins, Nichol E Holodick, Raja Vuyyuru, Tim Manser, Ruthee-Lu Bayer, Thomas L Rothstein

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. B1 Cells for Life.Immunological reviews · 2026
    Review
  3. Do human B-1 lymphocytes truly exist?Frontiers in immunology · 2026
    Review
  4. B-1a cells scavenge NETs to attenuate sepsis.Journal of leukocyte biology · 2024
    Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Ontogeny of human B1 cells.International journal of hematology · 2020
    Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Tâm D QuáchCenter for Oncology and Cell Biology, The Feinstein Institute for Medical Research, Manhasset, NY 11030.
Thomas J HopkinsCenter for Oncology and Cell Biology, The Feinstein Institute for Medical Research, Manhasset, NY 11030.ORCID 0000-0002-0670-4872
Nichol E HolodickCenter for Oncology and Cell Biology, The Feinstein Institute for Medical Research, Manhasset, NY 11030.ORCID 0000-0002-2671-6918
Raja VuyyuruDepartment of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107.ORCID 0000-0001-8648-658X
Tim ManserDepartment of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107.
Ruthee-Lu BayerMonter Cancer Center, North Shore University Hospital, Northwell Health, Lake Success, NY 11042; and.ORCID 0000-0002-3863-5621
Thomas L RothsteinCenter for Oncology and Cell Biology, The Feinstein Institute for Medical Research, Manhasset, NY 11030; tom.rothstein@med.wmich.edu.
Feinstein Institute for Medical Research · USNorthwell Health · USThomas Jefferson University · US

Funding

PHORBOL ESTER RESPONSIVE B LYMPHOCYTESR01AI029690 · NIAID · WESTERN MICHIGAN UNIV SCHOOL OF MEDICINE · PI ROTHSTEIN, THOMAS L · 1990 to 2019
$6.9M
NIAID NIH HHS R01 AI029690
6 · The paper itself

Abstract

The B-1 B cell population is an important bridge between innate and adaptive immunity primarily because B-1 cells produce natural Ab. Murine B-1 and B-2 cells arise from distinct progenitors; however, in humans, in part because it has been difficult to discriminate between them phenotypically, efforts to pinpoint the developmental origins of human B-1 and B-2 cells have lagged. To characterize progenitors of human B-1 and B-2 cells, we separated cord blood and bone marrow Lin

Indexed as

ADP-ribosyl Cyclase 1AnimalsAnimals, NewbornAntigens, CD19Antigens, CD34B-Lymphocyte SubsetsBone MarrowBone Marrow CellsCD24 AntigenCell SeparationFetal BloodHematologic NeoplasmsHematopoietic Stem CellsHematopoietic Stem Cell TransplantationHumansMiceADP-ribosyl Cyclase 1Antigens, CD19Antigens, CD34CD24 Antigen

Identifiers

PMID27815443
PMCPMC5363078
OpenAlexW2528397974

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.