Evidence map›Paper›PMID 27815390›Full record

ArticleCancer research2017

Kv1.3 Channels Mark Functionally Competent CD8+ Tumor-Infiltrating Lymphocytes in Head and Neck Cancer.

Ameet A Chimote, Peter Hajdu, Alexandros M Sfyris, Brittany N Gleich, Trisha Wise-Draper, Keith A Casper, Laura Conforti

Open access · bronzeAbstract read
In one paragraph

Article in Cancer research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 53 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Presetting CAR-T cells during ex vivo biomanufacturing.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Review
  7. Article
  8. Activity of Potassium Channels in CD8International journal of molecular sciences · 2024
    Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Store-Operated CaCancers · 2022
    Article
  16. Article
  17. Review
  18. Ionic Regulation of T-Cell Function and Anti-Tumour Immunity.International journal of molecular sciences · 2021
    Review
  19. Targeted knockdown of the adenosine AMolecular therapy. Methods & clinical development · 2021
    Article
  20. Ion Channel Dysregulation in Head and Neck Cancers: Perspectives for Clinical Application.Reviews of physiology, biochemistry and pharmacology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Ameet A ChimoteDepartment of Internal Medicine, Division of Nephrology, University of Cincinnati, Cincinnati, Ohio.
Peter HajduDepartment of Internal Medicine, Division of Nephrology, University of Cincinnati, Cincinnati, Ohio.
Alexandros M SfyrisDepartment of Internal Medicine, Division of Nephrology, University of Cincinnati, Cincinnati, Ohio.
Brittany N GleichDepartment of Internal Medicine, Division of Nephrology, University of Cincinnati, Cincinnati, Ohio.
Trisha Wise-DraperDepartment of Internal Medicine, Division of Hematology/Oncology, University of Cincinnati, Cincinnati, Ohio.
Keith A CasperDepartment of Otolaryngology, University of Michigan, Ann Arbor, Michigan.
Laura ConfortiDepartment of Internal Medicine, Division of Nephrology, University of Cincinnati, Cincinnati, Ohio. laura.conforti@uc.edu.
University of Cincinnati · USUniversity of Michigan · US

Funding

LCenter for Clinical and Translational Science and TrainingUL1TR001425 · NCATS · UNIVERSITY OF CINCINNATI · PI HEUBI, JAMES E., KISSELA, BRETT M · 2015 to 2024
$37.5M
ROLE OF ANGPTL4, AN ANGIOGENIC MEDIATOR, IN ARTHRITISP30AR047363 · NIAMS · CINCINNATI CHILDRENS HOSP MED CTR · PI THOMPSON, SUSAN D · 2001 to 2015
$9.2M
Tissue Repository CoreP30AR070549 · NIAMS · CINCINNATI CHILDRENS HOSP MED CTR · PI Leah Claire Kottyan · 2016 to 2026
$7.7M
KL2 Training ProgramKL2TR001426 · NCATS · UNIVERSITY OF CINCINNATI · PI ZELLER, MARGARET H · 2015 to 2024
$6.8M
Hypoxia and Potassium Channel Activity in T LymphocytesR01CA095286 · NCI · UNIVERSITY OF CINCINNATI · PI CONFORTI, LAURA · 2003 to 2019
$4.1M
NCI NIH HHS R01 CA095286
6 · The paper itself

Abstract

Tumor-infiltrating lymphocytes (TIL) are potent mediators of an antitumor response. However, their function is attenuated in solid tumors. CD8

Indexed as

AgedCalciumCarcinoma, Squamous CellCD8-Positive T-LymphocytesCell SeparationFemaleFlow CytometryFluorescent Antibody TechniqueHead and Neck NeoplasmsHumansImage Processing, Computer-AssistedImmunohistochemistryKv1.3 Potassium ChannelLymphocytes, Tumor-InfiltratingMaleMiddle AgedCalciumKv1.3 Potassium Channel

Identifiers

PMID27815390
PMCPMC5215046
OpenAlexW2547279377

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.