Evidence map›Paper›PMID 27815367›Full record

Observational studyJournal of applied physiology (Bethesda, Md. : 1985)2017

Nasal high-flow therapy reduces work of breathing compared with oxygen during sleep in COPD and smoking controls: a prospective observational study.

Paolo J C Biselli, Jason P Kirkness, Ludger Grote, Kathrin Fricke, Alan R Schwartz, Philip Smith, Hartmut Schneider

Registry-linked trialOpen access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of applied physiology (Bethesda, Md. : 1985), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03466385 (Nasal High Flow Versus Non-Invasive Ventilation in Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease), which is not on this map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
6.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03466385 naunknown statusnot on this mapstarted 2018, after this paper: background citation

Nasal High Flow Versus Non-Invasive Ventilation in Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease

TypeinterventionalSponsorEvangelismos HospitalRan2018 to 2021Enrolled498ConditionsChronic Obstructive Pulmonary Disease, Respiratory Failure, Acute Exacerbation CopdArmsNasal High Flow, Non-Invasive Ventilation
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Hospital Cost Savings for Sequential COPD Patients Receiving Domiciliary Nasal High Flow Therapy.International journal of chronic obstructive pulmonary disease · 2022
    Trial
  4. Development in PaCOBMJ open respiratory research · 2020
    Trial
  5. Trial
  6. Physiological effects of high-flow nasal cannula therapy in preterm infants.Archives of disease in childhood. Fetal and neonatal edition · 2020
    Trial
  7. Nasal high-flow versus noninvasive ventilation in patients with chronic hypercapnic COPD.International journal of chronic obstructive pulmonary disease · 2019
    Trial
  8. Trial
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Nasal high-flow oxygenERJ open research · 2020
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 3 countries.

Paolo J C BiselliJohns Hopkins Sleep Disorder Center, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland; p_biselli@hotmail.com.
Jason P KirknessJohns Hopkins Sleep Disorder Center, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland.
Ludger GroteCenter of Sleep and Vigilance Disorders, Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Kathrin FrickeJohns Hopkins Sleep Disorder Center, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland.
Alan R SchwartzJohns Hopkins Sleep Disorder Center, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland.
Philip SmithJohns Hopkins Sleep Disorder Center, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland.
Hartmut SchneiderJohns Hopkins Sleep Disorder Center, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland.
Johns Hopkins University · USUniversity of Gothenburg · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with chronic obstructive pulmonary disease (COPD) endure excessive resistive and elastic loads leading to chronic respiratory failure. Oxygen supplementation corrects hypoxemia but is not expected to reduce mechanical loads. Nasal high-flow (NHF) therapy supports breathing by reducing dead space, but it is unclear how it affects mechanical loads of patients with COPD. The objective of this study was to compare the effects of low-flow oxygen and NHF therapy on ventilation and work of breathing (WOB) in patients with COPD and controls during sleep. Patients with COPD (n = 12) and controls (n = 6) were recruited and submitted to polysomnography to measure sleep parameters and ventilation in response to administration of oxygen and NHF. A subset of six patients also had an esophageal catheter inserted for the purpose of measuring WOB. Patients with COPD had similar minute ventilation (V̇e) but lower tidal volumes than matched controls. With oxygen, [Formula: see text]was increased and V̇e was reduced in both controls and patients with COPD, but there was an increase in transcutaneous CO NEW & NOTEWORTHY: Nasal high-flow (NHF) therapy can support ventilation in patients with chronic obstructive pulmonary disease during sleep by decreasing the work of breathing and improving CO

Indexed as

Carbon DioxideFemaleHumansMaleMiddle AgedNasal MucosaOxygenProspective StudiesPulmonary Disease, Chronic ObstructivePulmonary VentilationRespirationRespiratory InsufficiencySleepSmokingTidal VolumeWork of BreathingCarbon DioxideOxygenCOPDnasal high flowoxygensleepwork of breathing

Identifiers

PMID27815367
PMCPMC5283854
OpenAlexW2548039159

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.