Evidence map›Paper›PMID 27815365›Full record

ArticleThe Journal of pharmacology and experimental therapeutics2017

Xanthohumol Modulates Calcium Signaling in Rat Ventricular Myocytes: Possible Antiarrhythmic Properties.

Juan Jose Arnaiz-Cot, Lars Cleemann, Martin Morad

Open access · greenAbstract read
In one paragraph

Article in The Journal of pharmacology and experimental therapeutics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Juan Jose Arnaiz-CotCardiac Signaling Center of University of South Carolina, Medical University of South Carolina, and Clemson University, Charleston, South Carolina.
Lars CleemannCardiac Signaling Center of University of South Carolina, Medical University of South Carolina, and Clemson University, Charleston, South Carolina.
Martin MoradCardiac Signaling Center of University of South Carolina, Medical University of South Carolina, and Clemson University, Charleston, South Carolina moradm@musc.edu.
Clemson University · USMedical University of South Carolina · US

Funding

ELECTROPHYSIOLOGY OF NEONATAL AND ADULT HEARTSR01HL016152 · NHLBI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI MORAD, MARTIN · 1985 to 2014
$4.5M
NHLBI NIH HHS R01 HL016152
6 · The paper itself

Abstract

Cardiac arrhythmia is a major cause of mortality in cardiovascular pathologies. A host of drugs targeted to sarcolemmal Na

Indexed as

AnimalsAnti-Arrhythmia AgentsCalcium SignalingDose-Response Relationship, DrugElectric StimulationFlavonoidsHeart VentriclesIsoproterenolMaleMyocytes, CardiacPropiophenonesRatsRats, Sprague-DawleyReactive Oxygen SpeciesRyanodine Receptor Calcium Release ChannelSarcoplasmic ReticulumAnti-Arrhythmia AgentsFlavonoidsIsoproterenolPropiophenonesReactive Oxygen SpeciesRyanodine Receptor Calcium Release ChannelRyR2 protein, ratxanthohumol

Identifiers

PMID27815365
PMCPMC5193078
OpenAlexW2547483045

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.