Evidence map›Paper›PMID 27815356›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2017

KTN0158, a Humanized Anti-KIT Monoclonal Antibody, Demonstrates Biologic Activity against both Normal and Malignant Canine Mast Cells.

Cheryl A London, Heather L Gardner, Sarah Rippy, Gerald Post, Krista La Perle, Linda Crew, Lori Lopresti-Morrow, Andrew J Garton, Gerald McMahon, Theresa M LaVallee and 1 more

Abstract read
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Review
  6. Mast Cells and Resistance to Immunotherapy in Cancer.Archivum immunologiae et therapiae experimentalis · 2023
    Review
  7. Article
  8. KIT as a master regulator of the mast cell lineage.The Journal of allergy and clinical immunology · 2022
    Review
  9. Review
  10. Review
  11. Review
  12. Emerging therapeutic targets for neuroblastoma.Expert opinion on therapeutic targets · 2020
    Review
  13. Review
  14. Review
  15. CD117 (c-Kit) Is Expressed During CD8Frontiers in immunology · 2019
    Article
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Cheryl A LondonDepartment of Veterinary Biosciences, The Ohio State University, Columbus, Ohio. london.20@osu.edu.
Heather L GardnerDepartment of Veterinary Clinical Sciences, The Ohio State University, Columbus, Ohio.
Sarah RippyDepartment of Veterinary Clinical Sciences, The Ohio State University, Columbus, Ohio.
Gerald PostThe Veterinary Cancer Center, Norwalk, Connecticut.
Krista La PerleDepartment of Veterinary Biosciences, The Ohio State University, Columbus, Ohio.
Linda CrewKolltan Pharmaceuticals, Inc., New Haven, Connecticut.
Lori Lopresti-MorrowKolltan Pharmaceuticals, Inc., New Haven, Connecticut.
Andrew J GartonKolltan Pharmaceuticals, Inc., New Haven, Connecticut.
Gerald McMahonKolltan Pharmaceuticals, Inc., New Haven, Connecticut.
Theresa M LaValleeKolltan Pharmaceuticals, Inc., New Haven, Connecticut.
Richard GedrichKolltan Pharmaceuticals, Inc., New Haven, Connecticut.
Achillion Pharmaceuticals (United States) · USThe Ohio State University · USNorwalk Hospital · US

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Tasleem J Padamsee · 1985 to 2026
$132.3M
The Ohio State University Center for clinical and Translational ScienceUL1TR001070 · NCATS · OHIO STATE UNIVERSITY · PI JACKSON, REBECCA D · 2013 to 2017
$22.6M
NCATS NIH HHS UL1 TR001070NCI NIH HHS P30 CA016058
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsAntibodies, MonoclonalCell ProliferationDog DiseasesDogsFemaleHumansMast CellsMutationPhosphorylationProto-Oncogene Proteins c-kitAntibodies, MonoclonalProto-Oncogene Proteins c-kit

Identifiers

PMID27815356
PMCPMC5418113
OpenAlexW2547273030

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.