Evidence map›Paper›PMID 27815355›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2017

Multiplex Genome Editing to Generate Universal CAR T Cells Resistant to PD1 Inhibition.

Jiangtao Ren, Xiaojun Liu, Chongyun Fang, Shuguang Jiang, Carl H June, Yangbing Zhao

Abstract read
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 603 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
603citing papers in PubMed, 2 pooled it
39.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

603 citing papers in PubMed, 2 syntheses or guidelines pooled it, 917 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Overview of Delivery Methods for Gene Editing.Methods in molecular biology (Clifton, N.J.) · 2027
    Review
  5. CRISPR/Cas Systems: Biological Basis and Genome Editing Applications.Methods in molecular biology (Clifton, N.J.) · 2027
    Review
  6. Review
  7. Review
  8. Article
  9. Advances inMolecular therapy. Nucleic acids · 2026
    Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Article
  16. Review
  17. Review
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  19. Article
  20. Review

543 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jiangtao RenAbramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania.
Xiaojun LiuAbramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania.
Chongyun FangAbramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania.
Shuguang JiangAbramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania.
Carl H JuneAbramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania. Yangbing@exchange.upenn.edu cjune@exchange.upenn.edu.
Yangbing ZhaoAbramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania. Yangbing@exchange.upenn.edu cjune@exchange.upenn.edu.
University of Pennsylvania · USParker Institute for Cancer Immunotherapy · US

Funding

UNIVERSITY OF PENNSYLVANIA CAN CTR SUPPORT GRANTP30CA016520 · NCI · UNIVERSITY OF PENNSYLVANIA · PI SHELLEY L BERGER · 1985 to 2026
$222.3M
IMMUNOTHERAPY WITH CAR T CELLSR01CA120409 · NCI · UNIVERSITY OF PENNSYLVANIA · PI JUNE, CARL H., ZHAO, YANGBING · 2006 to 2016
$2.7M
NCI NIH HHS P30 CA016520NCI NIH HHS R01 CA120409
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Gene EditingCRISPR-Cas SystemsGraft vs Host DiseaseHumansImmunotherapy, AdoptiveLymphocyte ActivationNeoplasmsProgrammed Cell Death 1 ReceptorReceptors, Antigen, T-CellSevere Combined ImmunodeficiencyT-LymphocytesPDCD1 protein, humanProgrammed Cell Death 1 ReceptorReceptors, Antigen, T-Cell

Identifiers

PMID27815355
PMCPMC5413401
OpenAlexW2548694234

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.