ArticleG3 (Bethesda, Md.)2016
The First Scube3 Mutant Mouse Line with Pleiotropic Phenotypic Alterations.
Open access · greenAbstract read
In one paragraph
Article in G3 (Bethesda, Md.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Neurogenetic Disorders with Hearing Loss: Mechanisms, Classifications, and Emerging Insights.Current neurology and neuroscience reports · 2025Review
- Important Role of the Ihh Signaling Pathway in Initiating Early Cranial Remodeling and Morphological Specialization inAnimals : an open access journal from MDPI · 2023Article
- The biology of SCUBE.Journal of biomedical science · 2023Review
- Comparative analysis reveals epigenomic evolution related to species traits and genomic imprinting in mammals.Innovation (Cambridge (Mass.)) · 2023Article
- Aberrant paracrine signalling for bone remodelling underlies the mutant histone-driven giant cell tumour of bone.Cell death and differentiation · 2022Article
- Saturation mutagenesis defines novel mouse models of severe spine deformity.Disease models & mechanisms · 2021Article
- SCUBE3 loss-of-function causes a recognizable recessive developmental disorder due to defective bone morphogenetic protein signaling.American journal of human genetics · 2021Article
- Article
- Exome sequencing in families with severe mental illness identifies novel and rare variants in genes implicated in Mendelian neuropsychiatric syndromes.Psychiatry and clinical neurosciences · 2019Article
Corrections and comments
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Authors and funding
54 authors at 6 institutions in 2 countries.
Helmut FuchsGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.ORCID 0000-0002-5143-2677
Sibylle SabrautzkiGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.ORCID 0000-0002-3435-921X
Gerhard K H PrzemeckGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.ORCID 0000-0003-3730-3454
Stefanie LeuchtenbergerGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.ORCID 0000-0003-3730-3454
Bettina Lorenz-DepiereuxInstitute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Lore BeckerGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.ORCID 0000-0002-6890-4984
Birgit RathkolbGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.ORCID 0000-0003-1239-0547
Marion HorschGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Lillian GarrettGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Manuela A ÖstereicherGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.ORCID 0000-0003-4333-2366
Wolfgang HansGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.ORCID 0000-0002-1221-4108
Koichiro AbeDepartment of Life Science, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Japan.
Nobuho SagawaDepartment of Life Science, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Japan.
Jan RozmanGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.ORCID 0000-0002-8035-8904
Ingrid L Vargas-PanessoGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.ORCID 0000-0001-5682-8454
Michael SandholzerGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Thomas S LisseGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Thure AdlerGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.ORCID 0000-0001-5434-9521
Juan Antonio Aguilar-PimentelGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.ORCID 0000-0002-4694-7107
Julia Calzada-WackGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Nicole EhrhardGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Ralf ElvertGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Christine GauGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.ORCID 0000-0002-4262-3071
Sabine M HölterGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.ORCID 0000-0003-4878-5241
Katja MicklichGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Kristin MorethGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.ORCID 0000-0001-7170-5284
Cornelia PrehnGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.ORCID 0000-0002-1274-4715
Oliver PukGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.ORCID 0000-0002-4302-6513
Ildiko RaczInstitute of Molecular Psychiatry, Medical Faculty, University of Bonn, 53127, Germany.ORCID 0000-0001-7329-0641
Claudia StoegerGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.ORCID 0000-0001-8361-0274
Alexandra VernalekenGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Dian MichelGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Susanne DienerInstitute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Thomas WielandInstitute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Jerzy AdamskiGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.ORCID 0000-0001-9259-0199
Raffi BekeredjianDivision of Cardiology, University of Heidelberg, 69120, Germany.
Dirk H BuschInstitute for Medical Microbiology, Immunology and Hygiene, Technische Universität München, 81675, Germany.ORCID 0000-0001-8713-093X
John FavorInstitute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Jochen GrawInstitute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.ORCID 0000-0003-0298-9660
Martin KlingensporElse Kröner Fresenius Center for Nutritional Medicine, Technische Universität München, 85350 Freising-Weihenstephan, Germany.ORCID 0000-0002-4502-6664
Christoph LenggerGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.ORCID 0000-0002-2207-4153
Holger MaierGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.ORCID 0000-0003-2514-8290
Frauke NeffGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Markus OllertDepartment of Dermatology and Allergy, Biederstein, Klinikum Rechts der Isar, Technische Universität München, 80802, Germany.
Tobias StoegerInstitute of Lung Biology and Diseases Member of the German Center for Lung Research (DZL), Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.ORCID 0000-0002-2790-0389
Ali Önder YildirimInstitute of Lung Biology and Diseases Member of the German Center for Lung Research (DZL), Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.ORCID 0000-0003-1969-480X
Tim M StromInstitute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Andreas ZimmerInstitute of Molecular Psychiatry, Medical Faculty, University of Bonn, 53127, Germany.ORCID 0000-0003-3127-287X
Eckhard WolfMolecular Animal Breeding and Biotechnology, Gene Center of the Ludwig-Maximilians-Universität München, 81377, Germany.ORCID 0000-0002-0430-9510
Wolfgang WurstInstitute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Thomas KlopstockDepartment of Neurology, Friedrich-Baur-Institut, Ludwig-Maximilians-Universität München, 80336, Germany.ORCID 0000-0003-2805-4652
Johannes BeckersGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.ORCID 0000-0001-7874-3822
Valerie Gailus-DurnerGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Martin Hrabé de AngelisGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany hrabe@helmholtz-muenchen.de.ORCID 0000-0002-7898-2353
Helmholtz Zentrum München · DEDeutsches Diabetes-Zentrum e.V. · DEGerman Center for Diabetes Research · DEGerman Center for Neurodegenerative Diseases · DEHeinrich Heine University Düsseldorf · DELuxembourg Institute of Health · LU
Funding
No grant is acknowledged in the PubMed record.
Abstract
The vertebrate Scube (Signal peptide, CUB, and EGF-like domain-containing protein) family consists of three independent members, Scube1-3, which encode secreted cell surface-associated membrane glycoproteins. Limited information about the general function of this gene family is available, and their roles during adulthood. Here, we present the first Scube3 mutant mouse line (Scube3
Indexed as
Genetic Association StudiesMutationPhenotypeAnimalsBone and BonesCalcium-Binding ProteinsChromosome MappingDisease Models, AnimalEnergy MetabolismExomeFemaleGene Expression ProfilingGlycoproteinsHigh-Throughput Nucleotide SequencingKidneyKidney Function TestsCalcium-Binding ProteinsGlycoproteinsScube3 protein, mousemouse modelPaget disease of bone (PDB)pleitropySCUBE3systemic phenotype
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