ReviewPathogens and disease2016
Thermoregulation as a disease tolerance defense strategy.
Review in Pathogens and disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 88 citations in OpenAlex.
- Homeothermy, microclimate and heat tolerance: Evolutionary origins, mechanisms and survival.International journal of biometeorology · 2026Review
- The poikilothermic hypothesis of sepsis.Critical care (London, England) · 2026Review
- Thermal comfort in relation to housing and tuberculosis status among individuals aged ≥15 years in Padang, West Sumatra Province, Indonesia.Frontiers in public health · 2026Article
- Mismatched and underrepresented: bat-virus diversity and phylogeographic bias in experimental infection studies.Frontiers in immunology · 2026Review
- Fc-modification of anti-PcrV gene-encoded antibodies modulates complement-mediated killing of Pseudomonas aeruginosa.Frontiers in immunology · 2025Article
- The immunology of sickness metabolism.Cellular & molecular immunology · 2024Review
- DecipheringmSystems · 2024Article
- Grouped mixtures of air pollutants and seasonal temperature anomalies and cardiovascular hospitalizations among U.S. Residents.Environment international · 2024Article
- Criteria to achieve safe antimicrobial intravenous-to-oral switch in hospitalised adult populations: a systematic rapid review.BMJ open · 2023Article
- The hypothermic nature of fungi.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Infection burdens and virulence under heat stress: ecological and evolutionary considerations.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Transient Receptor Potential Ankyrin-1-expressing vagus nerve fibers mediate IL-1β induced hypothermia and reflex anti-inflammatory responses.Molecular medicine (Cambridge, Mass.) · 2023Article
- Beyond energy balance regulation: The underestimated role of adipose tissues in host defense against pathogens.Frontiers in immunology · 2023Review
- Thermoregulatory dynamics reveal sex-specific inflammatory responses to experimental autoimmune encephalomyelitis in mice: Implications for multiple sclerosis-induced fatigue in females.Brain, behavior, & immunity - health · 2022Article
- Genetic background influences survival of infections with Salmonella enterica serovar Typhimurium in the Collaborative Cross.PLoS genetics · 2022Article
- Review
- Innate immunity, inflammation activation and heat-shock protein in COVID-19 pathogenesis.Journal of neuroimmunology · 2021Review
- The effects of aging on host resistance and disease tolerance to SARS-CoV-2 infection.The FEBS journal · 2021Review
- Pathophysiology of Fever and Application of Infrared Thermography (IRT) in the Detection of Sick Domestic Animals: Recent Advances.Animals : an open access journal from MDPI · 2021Review
- BAM15, a Mitochondrial Uncoupling Agent, Attenuates Inflammation in the LPS Injection Mouse Model: An Adjunctive Anti-Inflammation on Macrophages and Hepatocytes.Journal of innate immunity · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Physiological responses that occur during infection are most often thought of in terms of effectors of microbial destruction through the execution of resistance mechanisms, due to a direct action of the microbe, or are maladaptive consequences of host-pathogen interplay. However, an examination of the cellular and organ-level consequences of one such response, thermoregulation that leads to fever or hypothermia, reveals that these actions cannot be readily explained within the traditional paradigms of microbial killing or maladaptive consequences of host-pathogen interactions. In this review, the concept of disease tolerance is applied to thermoregulation during infection, inflammation and trauma, and we discuss the physiological consequences of thermoregulation during disease including tissue susceptibility to damage, inflammation, behavior and toxin neutralization.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.