ArticleAmerican journal of physiology. Lung cellular and molecular physiology2016
Age and testosterone mediate influenza pathogenesis in male mice.
Article in American journal of physiology. Lung cellular and molecular physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.
- Why does COVID-19 kill more elderly men than women? Is there a role for testosterone?Andrology · 2021Pooled it
- Dihydrotestosterone is a predictor for mortality in males with community-acquired pneumonia: results of a 6-year follow-up study.Respiratory research · 2018Trial
- Trimester-dependent vertical transmission of H5N1 influenza virus through placental and mammary routes impairs offspring development.Nature communications · 2026Article
- Biological sex influences immune response to influenza infection in juvenile outbred mice.American journal of physiology. Lung cellular and molecular physiology · 2026Article
- Sexual dimorphism of COVID-19 inspires drug repositioning and host-targeting immunotherapy for viral pneumonia.Signal transduction and targeted therapy · 2026Article
- Article
- Androgens are a Key Factor Affecting Immune Related Diseases.The world journal of men's health · 2026Review
- Host Factors Potentially Contributing to Increased Susceptibility in Certain Layer Chicken Lines.Current issues in molecular biology · 2026Review
- The influence of sex-specific factors on biological transformations and health outcomes in aging processes.Biogerontology · 2024Review
- The conneXion between sex and immune responses.Nature reviews. Immunology · 2024Review
- Sex Differences in the Immunogenicity and Efficacy of Seasonal Influenza Vaccines: A Meta-analysis of Randomized Controlled Trials.Open forum infectious diseases · 2024Article
- Article
- Mechanisms and consequences of sex differences in immune responses.Nature reviews. Nephrology · 2024Review
- H7N7 viral infection elicits pronounced, sex-specific neuroinflammatory responsesFrontiers in cellular neuroscience · 2024Article
- Transboundary determinants of avian zoonotic infectious diseases: challenges for strengthening research capacity and connecting surveillance networks.Frontiers in microbiology · 2024Review
- The Impact of Obesity on the Host-Pathogen Interaction with Influenza Viruses - Novel Insights: Narrative Review.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Review
- Adverse outcomes in SARS-CoV-2-infected pregnant mice are gestational age-dependent and resolve with antiviral treatment.The Journal of clinical investigation · 2023Article
- Comparison of different methods of initiating lung inflammation and the sex-specific effects on inflammatory parameters.American journal of physiology. Lung cellular and molecular physiology · 2023Article
- Sex chromosome complement and sex steroid signaling underlie sex differences in immunity to respiratory virus infection.Frontiers in pharmacology · 2023Review
- H7N9 avian influenza virus infection in men is associated with testosterone depletion.Nature communications · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Influenza severity increases with age, with hospitalization and mortality rates during seasonal influenza epidemics being higher in older men than age-matched women. As it is known that with age, circulating testosterone levels decline in males, we hypothesized that reduced testosterone contributes to age-associated increases in influenza severity. A murine model was used to test this hypothesis. As in men, testosterone concentrations were lower in aged (18 mo) than young (2 mo) male C57BL/6 mice. Following inoculation with influenza A virus (IAV), aged males experienced greater morbidity, clinical disease, and pulmonary inflammation than young males, and had lower neutralizing and total anti-influenza IgG antibody responses. Peak titers of virus in the lungs did not differ between aged and young males, but virus clearance was delayed in aged males. In young males, removal of the gonads increased-whereas treatment of gonadectomized males with testosterone reduced-morbidity, clinical illness, and pulmonary pathology, but viral replication was not altered by hormone manipulation in young males. Treatment of aged males with testosterone improved survival following infection but did not alter either virus replication or pulmonary pathology. These results indicate that low concentrations of testosterone, whether induced surgically in young males or naturally occurring in aged males, negatively impact the outcome of influenza.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.