Evidence map›Paper›PMID 27815066›Full record

ArticleThe journal of allergy and clinical immunology. In practice

Self-Reported Stressful Life Events During Adolescence and Subsequent Asthma: A Longitudinal Study.

Eyal Oren, Lynn Gerald, Debra A Stern, Fernando D Martinez, Anne L Wright

Abstract read
In one paragraph

Article in The journal of allergy and clinical immunology. In practice. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Child maltreatment and asthma.Pediatric pulmonology · 2022
    Review
  7. Review
  8. Article
  9. Article
  10. Chronic stress and asthma in adolescents.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2020
    Review
  11. Article
  12. Exposure to Violence, Psychosocial Stress, and Asthma.American journal of respiratory and critical care medicine · 2020
    Review
  13. Article
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Eyal OrenDepartment of Epidemiology and Biostatistics, College of Public Health, University of Arizona Health Sciences Center, Tucson, Ariz; Asthma and Airway Disease Research Center, College of Medicine, University of Arizona Health Sciences Center, Tucson, Ariz. Electronic address: eoren@email.arizona.edu.
Lynn GeraldAsthma and Airway Disease Research Center, College of Medicine, University of Arizona Health Sciences Center, Tucson, Ariz; Health Promotion Sciences, College of Public Health, University of Arizona Health Sciences Center, Tucson, Ariz.
Debra A SternAsthma and Airway Disease Research Center, College of Medicine, University of Arizona Health Sciences Center, Tucson, Ariz.
Fernando D MartinezAsthma and Airway Disease Research Center, College of Medicine, University of Arizona Health Sciences Center, Tucson, Ariz; Department of Pediatrics, College of Medicine, University of Arizona Health Sciences Center, Tucson, Ariz.
Anne L WrightAsthma and Airway Disease Research Center, College of Medicine, University of Arizona Health Sciences Center, Tucson, Ariz; Department of Pediatrics, College of Medicine, University of Arizona Health Sciences Center, Tucson, Ariz.

Funding

SOUTHWEST ENVIRONMENTAL HEALTH SCIENCES CENTERP30ES006694 · NIEHS · UNIVERSITY OF ARIZONA · PI DEAN BILLHEIMER · 1994 to 2026
$36.7M
ORBEX: Primary Prevention of Asthma and Wheezing in Children-CCC Lead ApplicationU01HL130045 · NHLBI · UNIVERSITY OF ARIZONA · PI MARTINEZ, FERNANDO D · 2016 to 2020
$22.4M
Controlling and preventing Asthma progression and Severity in Kids (CASK)U01AI126614 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI PHIPATANAKUL, WANDA · 2016 to 2023
$21.0M
Early Origins of Chronic Lung Disease: Outcomes into the Fifth Decade of LifeR01HL132523 · NHLBI · UNIVERSITY OF ARIZONA · PI Stefano Guerra, Fernando D Martinez · 2016 to 2026
$15.1M
Natural History of Asthma from Birth to Early Adult LifeR01HL056177 · NHLBI · UNIVERSITY OF ARIZONA · PI GUERRA, STEFANO, MARTINEZ, FERNANDO D · 1996 to 2015
$14.4M
Arizona/Duke Clinical Center for AsthmaNetU10HL098112 · NHLBI · UNIVERSITY OF ARIZONA · PI KRAFT, MONICA, MARTINEZ, FERNANDO D · 2009 to 2015
$4.7M
Regulation of Asthmatic Inflammation by Non-Muscle MLCKR01HL091889 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI GARCIA, JOE G. N., WANG, TING · 2008 to 2018
$3.2M
Serum Biomarkers of COPD: a population-based prospective studyR01HL095021 · NHLBI · UNIVERSITY OF ARIZONA · PI GUERRA, STEFANO · 2009 to 2013
$2.0M
NHLBI NIH HHS R01 HL056177NHLBI NIH HHS R01 HL091889NHLBI NIH HHS R01 HL095021NHLBI NIH HHS R01 HL132523NHLBI NIH HHS U01 HL130045NHLBI NIH HHS U10 HL098112NIAID NIH HHS U01 AI126614NIEHS NIH HHS P30 ES006694
6 · The paper itself

Abstract

backgroundAlthough exposure to stressful life events in adolescence has been associated with poor health as measured by number of physicians' visits and symptom scores, little is known regarding stress in adolescence and either concurrent or subsequent asthma.

objectiveThe objective of this study was to explore whether life events in adolescence are associated with either concurrent or new active asthma.

methodsThe Tucson Children's Respiratory Study, a prospective population-based birth cohort, surveyed participants at 10 ages between 6 and 29 years regarding respiratory health. Asthma was defined as a physician-diagnosis of asthma with symptoms during the previous year. At age 16, participants (n = 318) were queried regarding stressful life events using the 67-item Life Events Questionnaire for Adolescents (LEQA). LEQA scores were examined in relation to both concurrent and new active asthma. Estimates were obtained with logistic regression and mixed models.

resultsThere was no relation between asthma prevalence at age 16 and LEQA scores in the overall sample, although males with high LEQA scores had higher prevalence of asthma compared with males with low scores (relative risk [RR]: 3.03; 95% confidence interval [CI]: 1.37, 6.69; P = .006). Among adolescents with no asthma through age 16, risk of new asthma was greater for those with high LEQA scores (adjRR: 4.07; 95% CI: 1.33, 12.43; P = .014), after adjustment for potential confounders including smoking. Emotional support from family and friends slightly diminished the relation of stress to new asthma.

conclusionsStressful life events during adolescence are associated with subsequent new asthma. Additional biological and psychological measures of stress would complement these findings.

Indexed as

AdolescentAdultAsthmaChildFemaleHumansLongitudinal StudiesMalePrevalenceProspective StudiesSelf ReportSex FactorsSocial SupportStress, PsychologicalSurveys and QuestionnairesUnited StatesAdolescenceAsthmaStress

Identifiers

PMID27815066
PMCPMC5591640

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.