Evidence map›Paper›PMID 27814740›Full record

ArticleJournal of neuroinflammation2016

Spatio-temporal profile, phenotypic diversity, and fate of recruited monocytes into the post-ischemic brain.

Lidia Garcia-Bonilla, Giuseppe Faraco, Jamie Moore, Michelle Murphy, Gianfranco Racchumi, Jayashree Srinivasan, David Brea, Costantino Iadecola, Josef Anrather

Open access · goldAbstract read
In one paragraph

Article in Journal of neuroinflammation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 113 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Single-cell RNA sequencing in stroke and traumatic brain injury: Current achievements, challenges and future perspectives on transcriptomic profiling.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Review
  5. Article
  6. Monocyte-derived macrophages and their roles in ischemic stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Neural repair mechanisms after ischemic stroke.Inflammation and regeneration · 2025
    Review
  17. Review
  18. Article
  19. Article
  20. Article

24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Lidia Garcia-BonillaFeil Family Brain and Mind Research Institute, Weill Cornell Medicine, 407 East 61st Street RR409, New York, NY, 10065, USA.
Giuseppe FaracoFeil Family Brain and Mind Research Institute, Weill Cornell Medicine, 407 East 61st Street RR409, New York, NY, 10065, USA.
Jamie MooreFeil Family Brain and Mind Research Institute, Weill Cornell Medicine, 407 East 61st Street RR409, New York, NY, 10065, USA.
Michelle MurphyFeil Family Brain and Mind Research Institute, Weill Cornell Medicine, 407 East 61st Street RR409, New York, NY, 10065, USA.
Gianfranco RacchumiFeil Family Brain and Mind Research Institute, Weill Cornell Medicine, 407 East 61st Street RR409, New York, NY, 10065, USA.
Jayashree SrinivasanFeil Family Brain and Mind Research Institute, Weill Cornell Medicine, 407 East 61st Street RR409, New York, NY, 10065, USA.
David BreaFeil Family Brain and Mind Research Institute, Weill Cornell Medicine, 407 East 61st Street RR409, New York, NY, 10065, USA.
Costantino IadecolaFeil Family Brain and Mind Research Institute, Weill Cornell Medicine, 407 East 61st Street RR409, New York, NY, 10065, USA.
Josef AnratherFeil Family Brain and Mind Research Institute, Weill Cornell Medicine, 407 East 61st Street RR409, New York, NY, 10065, USA. joa2006@med.cornell.edu.
Cornell University · USMIND Research Institute · USWeill Cornell Medicine · US

Funding

NO SYNTHASE GENE EXPRESSION AND CEREBRAL ISCHEMIC DAMAGER01NS034179 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI IADECOLA, COSTANTINO · 1995 to 2021
$5.5M
Protective monocytes in cerebral ischemic toleranceR01NS081179 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI ANRATHER, JOSEF · 2012 to 2022
$3.7M
NO SYNTHASE GENE EXPRESSION AND CEREBRAL ISCHEMIC DAMAGER37NS034179 · NINDS · WEILL MEDICAL COLLEGE OF CORNELL UNIV · PI IADECOLA, COSTANTINO · 1999 to 2005
$1.8M
NINDS NIH HHS R01 NS034179NINDS NIH HHS R01 NS081179NINDS NIH HHS R37 NS034179
6 · The paper itself

Abstract

backgroundA key feature of the inflammatory response after cerebral ischemia is the brain infiltration of blood monocytes. There are two main monocyte subsets in the mouse blood: CCR2

methodsCX3CR1

resultsBrain mapping of CX3CR1

conclusionsCX3CR1

Indexed as

AnimalsBrainCalcium-Binding ProteinsCell MovementDisease Models, AnimalEndothelial CellsGene Expression RegulationGlucose Transporter Type 1Infarction, Middle Cerebral ArteryMaleMiceMice, Inbred C57BLMice, TransgenicMicrofilament ProteinsMonocytesMyocytes, Smooth MuscleAif1 protein, mouseCalcium-Binding ProteinsCcr2 protein, mouseGlucose Transporter Type 1Microfilament ProteinsNerve Tissue ProteinsNr4a1 protein, mouseNuclear Receptor Subfamily 4, Group A, Member 1Receptors, CCR2Receptors, Interleukin-8ASlc2a1 protein, mouseCCR2Cerebral ischemiaCX3CR1Ly6CMacrophagesMonocytes

Identifiers

PMID27814740
PMCPMC5097435
OpenAlexW2547755905

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.