Evidence map›Paper›PMID 27814650›Full record

ReviewFrontiers in bioscience (Landmark edition)2017

Mitochondrial transcription in mammalian cells.

Inna N Shokolenko, Mikhail F Alexeyev

Abstract readReview
In one paragraph

Review in Frontiers in bioscience (Landmark edition), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. SUV3 Helicase and Mitochondrial Homeostasis.International journal of molecular sciences · 2023
    Review
  8. Article
  9. Review
  10. Mitochondrial epigenetics in aging and cardiovascular diseases.Frontiers in cardiovascular medicine · 2023
    Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Expression Profile of MouseJournal of lifestyle medicine · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Inna N ShokolenkoUniversity of South Alabama, Patt Capps Covey College of Allied Health Professions, Biomedical Sciences Department, 5721 USA Drive N, HAHN 4021, Mobile, AL 36688-0002, USA.
Mikhail F AlexeyevDepartment of Physiology and Cell Biology, University of South Alabama, 5851 USA Dr. North, MSB3074, Mobile, AL 36688, USA, malexeye@southalabama.edu.

Funding

T-type Calcium Channels and von Willebrand Factor ReleaseP01HL066299 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI LEAVESLEY, SILAS JOSIAH · 2001 to 2022
$34.6M
Mouse models for mitochondrial disorders caused by mutations in mtDNAR01OD010944 · OD · UNIVERSITY OF SOUTH ALABAMA · PI ALEXEYEV, MIKHAIL F., WALLACE, DOUGLAS C · 2012 to 2020
$2.6M
Mouse models for mitochondrial disorders caused by mtDNA mutationsR01RR031286 · NCRR · UNIVERSITY OF SOUTH ALABAMA · PI ALEXEYEV, MIKHAIL F. · 2010 to 2011
$721k
NCRR NIH HHS R01 RR031286NHLBI NIH HHS P01 HL066299NIH HHS R01 OD010944
6 · The paper itself

Abstract

As a consequence of recent discoveries of intimate involvement of mitochondria with key cellular processes, there has been a resurgence of interest in all aspects of mitochondrial biology, including the intricate mechanisms of mitochondrial DNA maintenance and expression. Despite four decades of research, there remains a lot to be learned about the processes that enable transcription of genetic information from mitochondrial DNA to RNA, as well as their regulation. These processes are vitally important, as evidenced by the lethality of inactivating the central components of mitochondrial transcription machinery. Here, we review the current understanding of mitochondrial transcription and its regulation in mammalian cells. We also discuss key theories in the field and highlight controversial subjects and future directions as we see them.

Indexed as

Transcription, GeneticAdenosine TriphosphateAnimalsDNA-Directed RNA PolymerasesDNA, MitochondrialHumansMitochondriaMitochondrial ProteinsModels, BiologicalPromoter Regions, GeneticRNARNA, MitochondrialRNA Processing, Post-TranscriptionalTranscription FactorsTranscriptomeAdenosine TriphosphateDNA-Directed RNA PolymerasesDNA, MitochondrialMitochondrial ProteinsRNARNA, MitochondrialTranscription Factors

Identifiers

PMID27814650
PMCPMC5653244

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.