ArticleCell2016
From Whole-Brain Data to Functional Circuit Models: The Zebrafish Optomotor Response.
Article in Cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 158 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
158 citing papers in PubMed.
- Decay chemicals activate a pH-sensing pathway to initiate a persistent state.bioRxiv : the preprint server for biology · 2026Article
- An applicable and efficient retrograde monosynaptic circuit mapping tool for larval zebrafish.eLife · 2026Article
- Complex pectoral-fin-driven locomotion underlies refined visuomotor behavior in the cichlidiScience · 2026Article
- Whole-brain, all-optical interrogation of neuronal dynamics underlying gut and vascular interoception in zebrafish.Nature communications · 2026Article
- The Effects of Suspended Sediments, Dye, and Their Variation on Fish Behavior.Ecology and evolution · 2026Article
- Threshold-Free Neural Network Models for Swim Bout Detection of Larval Zebrafish.bioRxiv : the preprint server for biology · 2026Article
- Experience-dependent modulation of collective behavior in larval zebrafish.Nature communications · 2026Article
- MARINER: a surround visual stimulator for vision research in aquatic animals.bioRxiv : the preprint server for biology · 2026Article
- Swimming with robots: investigating fish locomotion, sensing, and schooling behavior with robotic swimmers.Nature communications · 2026Review
- Spatial Subdomains in the Optic Tectum for the Encoding of Visual Information.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Molecular and functional dissection using CaMPARI-seq reveals the neuronal organization for dissociating optic flow-dependent behaviors.Nature communications · 2026Article
- Review
- Article
- Visuomotor decision-making through multifeature convergence in the larval zebrafish hindbrain.Nature communications · 2026Article
- Developmental and genetic modulation of evidence integration dynamics in zebrafish sensorimotor decision-making.bioRxiv : the preprint server for biology · 2026Article
- Early life tributyltin exposure has long term physiological effects on the zebrafish (Danio rerio) visual system.Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2026Article
- Synchronization of behavioral and cardiac dynamics in larval zebrafish.Cell reports · 2026Article
- Myelin sheaths in the central nervous system can withstand damage and dynamically remodel.Science (New York, N.Y.) · 2026Article
- Astrocyte-induced internal state transitions reshape brainwide sensory, integrative, and motor computations.bioRxiv : the preprint server for biology · 2026Article
- Voltage imaging in zebrafish using high-speed light-sheet microscopy.Neurophotonics · 2026Review
98 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Detailed descriptions of brain-scale sensorimotor circuits underlying vertebrate behavior remain elusive. Recent advances in zebrafish neuroscience offer new opportunities to dissect such circuits via whole-brain imaging, behavioral analysis, functional perturbations, and network modeling. Here, we harness these tools to generate a brain-scale circuit model of the optomotor response, an orienting behavior evoked by visual motion. We show that such motion is processed by diverse neural response types distributed across multiple brain regions. To transform sensory input into action, these regions sequentially integrate eye- and direction-specific sensory streams, refine representations via interhemispheric inhibition, and demix locomotor instructions to independently drive turning and forward swimming. While experiments revealed many neural response types throughout the brain, modeling identified the dimensions of functional connectivity most critical for the behavior. We thus reveal how distributed neurons collaborate to generate behavior and illustrate a paradigm for distilling functional circuit models from whole-brain data.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.