Evidence map›Paper›PMID 27814453›Full record

Trial reportAmerican journal of respiratory and critical care medicine2017

Fluctuation Analysis of Peak Expiratory Flow and Its Association with Treatment Failure in Asthma.

David A Kaminsky, Lucy L Wang, Jason H T Bates, Cindy Thamrin, David M Shade, Anne E Dixon, Robert A Wise, Stephen Peters, Charles G Irvin

Abstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in American journal of respiratory and critical care medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
27.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Fluctuation Analysis of Peak Expiratory Flow and Its Association with Treatment Failure in Asthma.American journal of respiratory and critical care medicine · 2017
    Trial
  4. Article
  5. Article
  6. Article
  7. Review
  8. Late-onset asthma: current perspectives.Journal of asthma and allergy · 2018
    Review
  9. Review
  10. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

David A Kaminsky1 Pulmonary and Critical Care, University of Vermont College of Medicine, Burlington, Vermont.
Lucy L Wang2 Department of Biomedical Informatics and Medical Education, University of Washington School of Medicine, Seattle, Washington.
Jason H T Bates1 Pulmonary and Critical Care, University of Vermont College of Medicine, Burlington, Vermont.
Cindy Thamrin3 Woolcock Institute of Medical Research, Syndey, New South Wales, Australia.
David M Shade4 Pulmonary and Critical Care, Johns Hopkins University, Baltimore, Maryland; and.
Anne E Dixon1 Pulmonary and Critical Care, University of Vermont College of Medicine, Burlington, Vermont.
Robert A Wise4 Pulmonary and Critical Care, Johns Hopkins University, Baltimore, Maryland; and.
Stephen Peters5 Pulmonary and Critical Care Wake Forest School of Medicine, Winston-Salem, North Carolina.
Charles G Irvin1 Pulmonary and Critical Care, University of Vermont College of Medicine, Burlington, Vermont.
University of Vermont · USJohns Hopkins University · USUniversity of Washington · USWake Forest University · USWoolcock Institute of Medical Research · AU

Funding

University of Washington Biomedical Informatics and Data Science Research Training ProgramT15LM007442 · NLM · UNIVERSITY OF WASHINGTON · PI JOHN H. GENNARI, Andrea L. Hartzler · 2002 to 2026
$19.6M
Non-Allergic Late-Onset Asthma of Obesity: Pathophysiology and TherapyR01HL130847 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI BATES, JASON HT, DIXON, ANNE E · 2016 to 2019
$2.3M
NHLBI NIH HHS R01 HL130847NLM NIH HHS T15 LM007442
6 · The paper itself

Abstract

rationaleTemporal fluctuations have been demonstrated in lung function and asthma control, but the effect of controller therapy on these fluctuations is unknown.

objectivesTo determine if fluctuations in peak expiratory flow (PEF) are predictive of subsequent treatment failure and may be modified by controller therapy.

methodsWe applied detrended fluctuation analysis to once-daily PEF data from 493 participants in the LOCCS (Leukotriene Modifier Corticosteroid or Corticosteroid-Salmeterol) trial of the American Lung Association Airways Clinical Research Centers. We evaluated the coefficient of variation of PEF (CVpef) and the scaling exponent α, reflecting self-similarity of PEF, in relation to treatment failure from the run-in period of open-label inhaled fluticasone, and the treatment periods for subjects randomized to (1) continued twice daily fluticasone (F), (2) once daily fluticasone plus salmeterol (F + S), or (3) once daily oral montelukast (M). MEASUREMENTS AND MAIN

resultsThe CVpef was higher in those with treatment failure in the F and F + S groups in the run-in phase, and all three groups in the treatment phase. α was similar between those with and without treatment failure in all three groups during the run-in phase but was higher among those with treatment failure in the F and F + S groups during the treatment phase. Participants in all three groups showed variable patterns of change in α leading up to treatment failure.

conclusionsWe conclude that increased temporal self-similarity (α) of more variable lung function (CVpef) is associated with treatment failure, but the pattern of change in self-similarity leading up to treatment failure is variable across individuals.

Indexed as

AcetatesAdministration, InhalationAdultAnti-Asthmatic AgentsAsthmaBronchodilator AgentsCyclopropanesDrug Therapy, CombinationFemaleFluticasoneHumansMalePeak Expiratory Flow RateQuinolinesSalmeterol XinafoateSulfidesAcetatesAnti-Asthmatic AgentsBronchodilator AgentsCyclopropanesFluticasonemontelukastQuinolinesSalmeterol XinafoateSulfidesasthmafluctuation analysislung function variabilitypeak expiratory flowtreatment failure

Identifiers

PMID27814453
PMCPMC5803646
OpenAlexW2551873703

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.