Evidence map›Paper›PMID 27814430›Full record

ReviewJournal of biomechanical engineering2017

Computational Biomechanics of Human Red Blood Cells in Hematological Disorders.

Xuejin Li, He Li, Hung-Yu Chang, George Lykotrafitis, George Em Karniadakis

Open access · greenAbstract readReview
In one paragraph

Review in Journal of biomechanical engineering, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 60 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Xuejin LiDivision of Applied Mathematics, Brown University, Providence, RI 02912 e-mail: Xuejin_Li@brown.edu.
He LiDivision of Applied Mathematics, Brown University, Providence, RI 02912.
Hung-Yu ChangDivision of Applied Mathematics, Brown University, Providence, RI 02912.
George LykotrafitisDepartment of Mechanical Engineering, University of Connecticut, Storrs, CT 06269;Department of Biomedical Engineering, University of Connecticut, Storrs, CT 06269.
George Em KarniadakisFellow ASME Division of Applied Mathematics, Brown University, Providence, RI 02912 e-mail: George_Karniadakis@brown.edu.
Brown University · USUniversity of Connecticut · US

Funding

Multiscale Modeling of Sickle Cell Anemia: Methods and ValidationU01HL114476 · NHLBI · BROWN UNIVERSITY · PI DAO, MING, HIGGINS, JOHN MATTHEW · 2013 to 2017
$3.9M
Multiscale, Multiphysics Model of Thrombus Biomechanics in Aortic DissectionU01HL116323 · NHLBI · YALE UNIVERSITY · PI HUMPHREY, JAY D., KARNIADAKIS, GEORGE · 2013 to 2017
$2.4M
NHLBI NIH HHS U01 HL114476NHLBI NIH HHS U01 HL116323
6 · The paper itself

Abstract

We review recent advances in multiscale modeling of the biomechanical characteristics of red blood cells (RBCs) in hematological diseases, and their relevance to the structure and dynamics of defective RBCs. We highlight examples of successful simulations of blood disorders including malaria and other hereditary disorders, such as sickle-cell anemia, spherocytosis, and elliptocytosis.

Indexed as

Blood Flow VelocityModels, CardiovascularCell SizeCompressive StrengthComputer SimulationElastic ModulusErythrocytesHematologic DiseasesHumansRheologyShear StrengthStress, MechanicalTensile Strength

Identifiers

PMID27814430
PMCPMC5395917
OpenAlexW2546815243

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.