ArticlePloS one2016
Associations between Nausea, Vomiting, Fatigue and Health-Related Quality of Life of Women in Early Pregnancy: The Generation R Study.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 5 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 5 syntheses or guidelines pooled it, 93 citations in OpenAlex.
- The impact of nausea and vomiting on health related quality of life during pregnancy: a systematic review.BMC pregnancy and childbirth · 2025Pooled it
- Effects of strength training on quality of life in pregnant women: A systematic review.Acta obstetricia et gynecologica Scandinavica · 2025Pooled it
- An Evaluation of Food and Nutrient Intake among Pregnant Women in The Netherlands: A Systematic Review.Nutrients · 2023Pooled it
- Fatigue During Pregnancy: A Bibliometric Analysis.Maternal and child health journal · 2023Pooled it
- Food Consumption, Nutrient Intake and Status during the First 1000 days of Life in the Netherlands: a Systematic Review.Nutrients · 2019Pooled it
- Expectations predict early pregnancy-related symptom burden.Scientific reports · 2026Article
- The Australian MotherSafe enhanced service for nausea and vomiting in pregnancy and hyperemesis gravidarum: a mixed methods study.BMC pregnancy and childbirth · 2026Article
- A prospective study of periconceptional perceived stress and rate of miscarriage.Human reproduction (Oxford, England) · 2026Article
- A prospective multicenter register study exploring health-related quality of life in women with Sjögren's disease during pregnancy.Frontiers in global women's health · 2026Article
- The relationship between pregnancy complaints and obsessive-compulsive behaviors during the postpartum period regarding baby care: a cross-sectional study.BMC pregnancy and childbirth · 2025Article
- Quality of life in pregnant women with subclinical hypothyroidism: clinical management gaps.Thyroid research · 2025Article
- Assessing community pharmacists' responses to pregnancy-related nausea and vomiting: A national simulated patient study in Jordan.PloS one · 2025Observational
- A national study on maternal vomiting during pregnancy in Iran: prevalence, determinants, adverse birth outcomes, and the trend.BMC pregnancy and childbirth · 2024Article
- Association of Phenols, Parabens, and Their Mixture with Maternal Blood Pressure Measurements in the PROTECT Cohort.Environmental health perspectives · 2024Article
- The quality of life and work productivity are affected by the presence of nausea/vomiting in patients taking iron preparations for heavy menstrual bleeding or anemia: a population-based cross-sectional survey in Japan.BMC women's health · 2024Article
- Prevalence and course of pregnancy symptoms using self-reported pregnancy app symptom tracker data.NPJ digital medicine · 2023Article
- Impact of nausea/vomiting on EQ-5D-5L utility scores in patients taking iron preparations for heavy menstrual bleeding or anemia.BMC women's health · 2023Article
- Disability during Early Pregnancy: Using the Sheehan Disability Scale during the First Trimester in Japan.Healthcare (Basel, Switzerland) · 2022Article
- A longitudinal investigation of the influence of psychological factors on nausea and vomiting in early pregnancy.Archives of women's mental health · 2022Article
- Quality of Life instruments and their psychometric properties for use in parents during pregnancy and the postpartum period: a systematic scoping review.Health and quality of life outcomes · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this study was to evaluate the independent associations between nausea, vomiting, fatigue and health-related quality of life of women in early pregnancy in the Generation R study, which is a prospective mother and child cohort. Analyses were based on 5079 women in early pregnancy in the Rotterdam area, the Netherlands. The information on nausea, vomiting and fatigue in the previous three months was measured in the questionnaire at enrollment, as well as potential confounders (i.e., maternal/gestational age, ethnic background, educational level, parity, marital status, body mass index, tobacco and alcohol use, chronic/infectious conditions, uro-genital conditions/symptoms, sleep quality, headache, anxiety, and depression). Health-related quality of life was assessed by the 12-item Short Form Health Survey and physical and mental component summary scores were calculated. Multivariate regression models were performed to evaluate the independent associations of the presence of nausea, vomiting and fatigue with health-related quality of life, adjusting for potential confounders. 33.6% of women experienced daily presence of nausea, 9.6% for vomiting and 44.4% for fatigue. Comparing with women who never reported nausea, vomiting and fatigue, women with daily presence of at least one of these symptoms had significantly lower scores of physical component summary and mental component summary, after adjusting for potential confounders. Our study shows how common nausea, vomiting and fatigue are among women in early pregnancy and how much each of these symptoms negatively impact on health-related quality of life. We call for awareness of this issue from health care professionals, pregnant women and their families.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.