ArticleConnective tissue research
Matrix metalloproteinase activity and prostaglandin E2 are elevated in the synovial fluid of meniscus tear patients.
Article in Connective tissue research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 70 citations in OpenAlex.
- [Advances in immunomodulatory strategies for meniscal regeneration].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026Review
- Biologic Augmentation for Meniscus Repair: A Narrative Review.Bioengineering (Basel, Switzerland) · 2026Review
- Syringic Acid Attenuates the IL-1β-Induced Akt Pathway in Chondrocyte ATDC5 Cells.Combinatorial chemistry & high throughput screening · 2025Article
- Short-term response of primary human meniscus cells to simulated microgravity.Cell communication and signaling : CCS · 2024Article
- Molecular biomarker approaches to prevention of post-traumatic osteoarthritis.Nature reviews. Rheumatology · 2024Review
- Molecular Biology of Meniscal Healing: A Narrative Review.International journal of molecular sciences · 2024Review
- Earlier and More Severe Cartilage Degeneration Occurs After Meniscal Tears in Juvenile Rabbits Compared with Adults.Cartilage · 2023Article
- The Interplay of Biomechanical and Biological Changes Following Meniscus Injury.Current rheumatology reports · 2023Review
- Histologic and molecular features in pathologic human menisci from knees with and without osteoarthritis.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Article
- Article
- A Tale of Two Loads: Modulation of IL-1 Induced Inflammatory Responses of Meniscal Cells in Two Models of Dynamic Physiologic Loading.Frontiers in bioengineering and biotechnology · 2022Article
- Article
- Immune cell profiles in synovial fluid after anterior cruciate ligament and meniscus injuries.Arthritis research & therapy · 2021Article
- Post-Traumatic Osteoarthritis Assessment in Emerging and Advanced Pre-Clinical Meniscus Repair Strategies: A Review.Frontiers in bioengineering and biotechnology · 2021Review
- Advances in the Mechanisms Affecting Meniscal Avascular Zone Repair and Therapies.Frontiers in cell and developmental biology · 2021Review
- Histologically Confirmed Recellularization is a Key Factor that Affects Meniscal Healing in Immature and Mature Meniscal Tears.Frontiers in cell and developmental biology · 2021Article
- A representative metalloprotease induces PGEScientific reports · 2020Article
- Alternations of Metabolic Profiles in Synovial Fluids and the Correlation with T2 Relaxation Times of Cartilage and Meniscus-A Study on Anterior Cruciate Ligament- (ACL-) Injured Rabbit Knees at Early Stage.BioMed research international · 2019Article
- MMP-3 in the peripheral serum as a biomarker of knee osteoarthritis, 40 years after open total knee meniscectomy.Journal of experimental orthopaedics · 2018Article
- The Pathobiology of the Meniscus: A Comparison Between the Human and Dog.Frontiers in veterinary science · 2018Review
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 1 country.
Funding
Abstract
purposeMeniscus tears are a common knee injury and are associated with the development of post-traumatic osteoarthritis (OA). The purpose of this study is to evaluate potential OA mediators in the synovial fluid and serum of meniscus tear subjects compared to those in the synovial fluid of radiographic non-OA control knees. MATERIALS AND
methodsSixteen subjects with an isolated unilateral meniscus injury and six subjects who served as reference controls (knee Kellgren-Lawrence grade 0-1) were recruited. Twenty-one biomarkers were measured in serum from meniscus tear subjects and in synovial fluid from both groups. Meniscus tear subjects were further stratified by tear type to assess differences in biomarker levels.
resultsSynovial fluid total matrix metalloproteinase (MMP) activity and prostaglandin E2 (PGE2) were increased 25-fold and 290-fold, respectively, in meniscus tear subjects as compared to reference controls (p < 0.05). Synovial fluid MMP activity and PGE2 concentrations were positively correlated in meniscus tear subjects (R = 0.83, p < 0.0001). In meniscus tear subjects, synovial fluid levels of MMP activity, MMP-2, MMP-3, sGAG, COMP, IL-6, and PGE2 were higher than serum levels (p < 0.05). Subjects with complex meniscus tears had higher synovial fluid MMP-10 (p < 0.05) and reduced serum TNFα and IL-8 (p < 0.05) compared to other tear types.
conclusionsGiven the degradative and pro-inflammatory roles of MMP activity and PGE2, these molecules may alter the biochemical environment of the joint. Our findings suggest that modulation of PGE2 signaling, MMP activity, or both following a meniscus injury may be targets to promote meniscus repair and prevent OA development.
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