Evidence map›Paper›PMID 27813459›Full record

ArticleThe Clinical neuropsychologist2017

Marked brain asymmetry with intact cognitive functioning in idiopathic Parkinson's disease: a longitudinal analysis.

Jared J Tanner, Shellie-Anne Levy, Nadine A Schwab, Loren P Hizel, Peter T Nguyen, Michael S Okun, Catherine C Price

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in The Clinical neuropsychologist, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Freezing of Gait: A Tribute to Nir Giladi.The European journal of neuroscience · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jared J Tannera Department of Clinical and Health Psychology , University of Florida , Gainesville , FL , USA.
Shellie-Anne Levya Department of Clinical and Health Psychology , University of Florida , Gainesville , FL , USA.
Nadine A Schwaba Department of Clinical and Health Psychology , University of Florida , Gainesville , FL , USA.
Loren P Hizela Department of Clinical and Health Psychology , University of Florida , Gainesville , FL , USA.
Peter T Nguyena Department of Clinical and Health Psychology , University of Florida , Gainesville , FL , USA.
Michael S Okuna Department of Clinical and Health Psychology , University of Florida , Gainesville , FL , USA.
Catherine C Pricea Department of Clinical and Health Psychology , University of Florida , Gainesville , FL , USA.

Funding

Using social networks to map and evaluate team science across CTSA hubsUL1TR001427 · NCATS · UNIVERSITY OF FLORIDA · PI MITCHELL, DUANE A. · 2015 to 2024
$37.2M
University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI Karyn A Esser, Todd Manini · 2007 to 2026
$22.8M
UF Clinical and Translational Science AwardUL1TR000064 · NCATS · UNIVERSITY OF FLORIDA · PI NELSON, DAVID R · 2012 to 2014
$12.2M
Research Training in Non-Pharmacological Interventions for Cognition in Aging, MCI, and Alzheimer's DiseaseT32AG020499 · NIA · UNIVERSITY OF FLORIDA · PI MARSISKE, MICHAEL, SMITH, GLENN E. · 2003 to 2024
$3.7M
White Matter Connectivity and PD Cognitive PhenotypesR01NS082386 · NINDS · UNIVERSITY OF FLORIDA · PI PRICE, CATHERINE E · 2013 to 2017
$2.3M
White Matter and Cognition in Parkinson's DiseaseK23NS060660 · NINDS · UNIVERSITY OF FLORIDA · PI PRICE, CATHERINE E · 2007 to 2011
$619k
NCATS NIH HHS UL1 TR000064NCATS NIH HHS UL1 TR001427NIA NIH HHS P30 AG028740NIA NIH HHS T32 AG020499NINDS NIH HHS K23 NS060660NINDS NIH HHS R01 NS082386
6 · The paper itself

Abstract

objectiveA 71-year-old (MN) with an 11-year history of left onset tremor diagnosed as Parkinson's disease (PD) completed longitudinal brain magnetic resonance imaging (MRI) and neuropsychological testing. MRI scans showed an asymmetric caudate nucleus (right < left volume). We describe this asymmetry at baseline and the progression over time relative to other subcortical gray, frontal white matter, and cortical gray matter regions of interest. Isolated structural changes are compared to MN's cognitive profiles.

methodMN completed yearly MRIs and neuropsychological assessments. For comparison, left onset PD (n = 15) and non-PD (n = 43) peers completed the same baseline protocol. All MRI scans were processed with FreeSurfer and the FMRIB Software Library to analyze gray matter structures and frontal fractional anisotropy (FA) metrics. Processing speed, working memory, language, verbal memory, abstract reasoning, visuospatial, and motor functions were examined using reliable change methods.

resultsAt baseline, MN had striatal volume and frontal lobe thickness asymmetry relative to peers with mild prefrontal white matter FA asymmetry. Over time only MN's right caudate nucleus showed accelerated atrophy. Cognitively, MN had slowed psychomotor speed and visuospatial-linked deficits with mild visuospatial working memory declines longitudinally.

conclusionsThis is a unique report using normative neuroimaging and neuropsychology to describe an individual diagnosed with PD who had striking striatal asymmetry followed secondarily by cortical thickness asymmetry and possible frontal white matter asymmetry. His decline and variability in visual working memory could be linked to ongoing atrophy of his right caudate nucleus.

Indexed as

CognitionFunctional LateralityAgedAged, 80 and overAnisotropyDisease ProgressionFemaleFrontal LobeGray MatterHumansLanguage TestsLongitudinal StudiesMagnetic Resonance ImagingMaleMemoryMemory, Short-Termexecutive functionmemorymovement disordersNeuroimagingwhite matter

Identifiers

PMID27813459
PMCPMC5334434

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.