Evidence map›Paper›PMID 27813452›Full record

Trial reportNeurodegenerative disease management2016

Cognitive remediation to enhance mobility in older adults: the CREM study.

Joe Verghese, Emmeline Ayers, Jeannette R Mahoney, Anne Ambrose, Cuiling Wang, Roee Holtzer

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Neurodegenerative disease management, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Cognitive-Based Interventions to Improve Mobility: A Systematic Review and Meta-analysis.Journal of the American Medical Directors Association · 2018
    Pooled it
  2. Trial
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Joe VergheseDepartment of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA.
Emmeline AyersDepartment of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA.
Jeannette R MahoneyDepartment of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA.
Anne AmbroseBurke Rehabilitation Hospital, White Plains, NY, USA.
Cuiling WangDepartment of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.
Roee HoltzerDepartment of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA.

Funding

Core-010UL1TR001073 · NCATS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI KELLER, MARLA J, SHAMOON, HARRY · 2013 to 2017
$21.3M
Cognitive intervention to improve simple and complex walkingR01AG050448 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI HOLTZER, ROEE, VERGHESE, JOE · 2015 to 2019
$4.0M
NCATS NIH HHS UL1 TR001073NIA NIH HHS R01 AG050448
6 · The paper itself

Abstract

Mobility disabilities represent the most prevalent disability among seniors. Emerging evidence indicates that executive functions play an important role in maintaining mobility. However, the use of cognitive remediation programs to enhance mobility has not been investigated in a full-scale randomized control trial. The CREM study is a single-blind randomized control trial to examine the effect of computerized cognitive remediation versus computer-based health education training on mobility in 420 seniors. The primary outcome is change in gait speed during normal walking and walking-while-talking conditions from baseline to postintervention. Secondary outcomes are change in mobility, mobility-related cognitive processes and neuroplasticity. Results of this study will fill an important gap in the efficacy and feasibility of cognitive remediation to improve mobility in seniors.

Indexed as

Cognitive RemediationMobility LimitationTherapy, Computer-AssistedAgedAged, 80 and overExecutive FunctionGaitGait Disorders, NeurologicHumansPatient SelectionSingle-Blind MethodWalkingclinical trial protocolcognitive remediationexecutive functiongait velocity

Identifiers

PMID27813452
PMCPMC5134757

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.