Evidence map›Paper›PMID 27813347›Full record

Trial reportArthritis care & research2017

Early High-Intensity Versus Low-Intensity Rehabilitation After Total Knee Arthroplasty: A Randomized Controlled Trial.

Michael J Bade, Tamara Struessel, Michael Dayton, Jared Foran, Raymond H Kim, Todd Miner, Pamela Wolfe, Wendy M Kohrt, Douglas Dennis, Jennifer E Stevens-Lapsley

3 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Arthritis care & research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 63 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03227120 nacompletednot on this map

The Effects of Prehabilitative Exercise on Functional Recovery Following Total Knee Arthroplasty

TypeinterventionalSponsorCarilion ClinicRan2017 to 2020Enrolled60ConditionsArthroplasty, Osteoarthritis, KneeArmsPrehabilitation exercise
NCT04694625 nacompletednot on this mapstarted 2021, after this paper: background citation

Effects of Structured Rehabilitation Program on Pain and Function in Patients With Total Knee Replacement

TypeinterventionalSponsorRiphah International UniversityRan2021 to 2021Enrolled26ConditionsKneeArmsStructured Rehabilitation Program, Conventional Physical Therapy
NCT05190380 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Comparative effects of high and low intensity progressive resisted exercises on pain, range of motion and functional disability in knee osteoarthritis patients with sarcopenia: a randomized controlled trial

TypeinterventionalSponsorUniversity of LahoreRan2021 to 2022Enrolled84ConditionsOsteo Arthritis Knee, SarcopeniaArmsHIGH INTENSITY PROGRESSIVE RESISTED EXERCISE, LOW INTENSITY PROGRESSIVE RESISTED EXERCISE
3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Guideline
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Guideline
  8. Trial
  9. Trial
  10. Trial
  11. Trial
  12. Trial
  13. Trial
  14. Neuromuscular electrical stimulation preserves muscle strength early after total knee arthroplasty: Effects on muscle fiber size.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023
    Trial
  15. Trial
  16. Trial
  17. Trial
  18. Trial
  19. Trial
  20. Trial

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Michael J BadeUniversity of Colorado Anschutz Medical Campus, Aurora.
Tamara StruesselUniversity of Colorado Anschutz Medical Campus, Aurora.
Michael DaytonUniversity of Colorado Anschutz Medical Campus, Aurora.
Jared ForanThe Steadman Clinic and The Steadman Philippon Research Institute, Vail, Colorado.
Raymond H KimThe Steadman Clinic and The Steadman Philippon Research Institute, Vail, Colorado.
Todd MinerColorado Joint Replacement, Denver, Colorado.
Pamela WolfeUniversity of Colorado Anschutz Medical Campus, Aurora.
Wendy M KohrtUniversity of Colorado Anschutz Medical Campus, Aurora, and Geriatric Research Education and Clinical Center, VA Eastern Colorado Healthcare System, Denver, Colorado.
Douglas DennisColorado Joint Replacement, Denver, Colorado.
Jennifer E Stevens-LapsleyUniversity of Colorado Anschutz Medical Campus, Aurora, and Geriatric Research Education and Clinical Center, VA Eastern Colorado Healthcare System, Denver, Colorado.

Funding

Colorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0M
PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Wendy M Kohrt · 1995 to 2026
$32.6M
Colorado Clinical and Translational Science Institute (UL1)UL1TR000154 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2012 to 2013
$20.4M
University of Colorado Aging Training GrantT32AG000279 · NIA · UNIVERSITY OF COLORADO DENVER · PI Kerrie Moreau · 2001 to 2026
$10.1M
Progressive Rehabilitation for Total Knee ArthroplastyR01HD065900 · NICHD · UNIVERSITY OF COLORADO DENVER · PI STEVENS-LAPSLEY, JENNIFER E. · 2011 to 2015
$2.2M
NCATS NIH HHS UL1 TR000154NCATS NIH HHS UL1 TR001082NIA NIH HHS T32 AG000279NICHD NIH HHS R01 HD065900NIDDK NIH HHS P30 DK048520
6 · The paper itself

Abstract

objectiveTo examine the safety and efficacy of a high-intensity (HI) progressive rehabilitation protocol beginning 4 days after total knee arthroplasty (TKA) compared to a low-intensity (LI) rehabilitation protocol.

methodsA total of 162 participants (mean ± SD ages 63 ± 7 years; 89 women) were randomized to either the HI group or LI group after TKA. Key components of the HI intervention were the use of progressive resistance exercises and a rapid progression to weight-bearing exercises and activities. Both groups were treated in an outpatient setting 2 to 3 times per week for 11 weeks (26 total sessions). Outcomes included the stair climbing test (SCT; primary outcome), timed-up-and-go (TUG) test, 6-minute walk (6MW) test, the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), 12-item Short Form health survey (SF-12), knee range of motion (ROM), quadriceps and hamstring strength, and quadriceps activation. Outcomes were assessed preoperatively and at 1, 2, 3 (primary end point), 6, and 12 months postoperatively.

resultsThere were no significant differences between groups at 3 or 12 months in SCT, TUG, 6MW, WOMAC scores, knee ROM, quadriceps and hamstrings strength, quadriceps activation, or adverse event rates. By 12 months, outcomes on the 6MW, TUG, WOMAC, SF-12, quadriceps and hamstring strength, and quadriceps activation had improved beyond baseline performance in both groups.

conclusionBoth the HI and LI interventions were effective in improving strength and function after TKA. HI progressive rehabilitation is safe for individuals after TKA. However, its effectiveness may be limited by arthrogenic muscular inhibition in the early postoperative period.

Indexed as

AgedArthroplasty, Replacement, KneeExercise TestExercise TherapyFemaleHamstring MusclesHigh-Intensity Interval TrainingHumansKnee JointMaleMiddle AgedMuscle StrengthOsteoarthritis, KneeQuadriceps MuscleRange of Motion, ArticularRecovery of Function

Identifiers

PMID27813347
PMCPMC5415445

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.