ArticleJournal of biomedical materials research. Part A2017
Bone-forming cells with pronounced spread into the third dimension in polymer scaffolds fabricated by two-photon polymerization.
Article in Journal of biomedical materials research. Part A, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- 3D Printing of Bone Substitutes Based on Vat Photopolymerization Processes: A Systematic Review.Journal of tissue engineering and regenerative medicine · 2023Pooled it
- Hybrid Multiphoton Lithography Scaffolds for Nanoscale Mechanobiological Assessment in Microscale Bone Models.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Additive manufacturing for Dentistry: A comprehensive review of techniques and applications.Progress in materials science · 2026Article
- Bioactive Glass Microscaffolds Fabricated by Two-Photon Lithography.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Direct laser writing-enabled 3D printing strategies for microfluidic applications.Lab on a chip · 2024Review
- Two-Photon Polymerization: Fundamentals, Materials, and Chemical Modification Strategies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Review
- Optimization mechanism and applications of ultrafast laser machining towards highly designable 3D micro/nano structuring.RSC advances · 2022Review
- From Light to Structure: Photo Initiators for Radical Two-Photon Polymerization.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Review
- Two-photon polymerization for 3D biomedical scaffolds: Overview and updates.Frontiers in bioengineering and biotechnology · 2022Review
- Femtosecond Laser-Processing of Pre-Anodized Ti-Based Bone Implants for Cell-Repellent Functionalization.Nanomaterials (Basel, Switzerland) · 2021Article
- Applications of nanotechnology in 3D printed tissue engineering scaffolds.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V · 2021Review
- Challenges on optimization of 3D-printed bone scaffolds.Biomedical engineering online · 2020Review
- 3D multiphoton lithography using biocompatible polymers with specific mechanical properties.Nanoscale advances · 2020Article
- Water-Soluble Photoinitiators in Biomedical Applications.Polymers · 2020Review
- Collagen-Based Medical Device as a Stem Cell Carrier for Regenerative Medicine.International journal of molecular sciences · 2017Article
- Bone-forming cells with pronounced spread into the third dimension in polymer scaffolds fabricated by two-photon polymerization.Journal of biomedical materials research. Part A · 2017Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The main aim of this work was to stimulate bone-forming cells to produce three-dimensional networks of mineralized proteins such as those occurring in bones. This was achieved by a novel approach using a specific type of mesenchymal progenitor cells (i.e., primary fibroblast cells from human hair roots) seeded on to polymer scaffolds. We wrote polymer microstructures with one or more levels of quadratic pores on to a flexible substrate by means of two-photon polymerization using a Ti-sapphire femtosecond laser focused into a liquid acrylate-based resin containing a photoinitiator. Progenitor cells, differentiated into an osteogenic lineage by the use of medium supplemented with biochemical stimuli, can be seeded on to the hydrophilic three-dimensional scaffolds. Due to confinement to the microstructures and/or mechanical interaction with the scaffold, the cells are stimulated to produce high amounts of calcium-binding proteins, such as collagen type I, and show an increased activation of the actin cytoskeleton. The best results were obtained for quadratic pore sizes of 35 µm: the pore volumes become almost filled with both cells in close contact with the walls of the structure and with extracellular matrix material produced by the cells. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 891-899, 2017.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.