ArticleAngewandte Chemie (International ed. in English)2016
Nickel-Catalyzed Chemo- and Enantioselective Coupling between Cyclobutanones and Allenes: Rapid Synthesis of [3.2.2] Bicycles.
Article in Angewandte Chemie (International ed. in English), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Catalytic asymmetric intermolecular [4 + 2] annulation of benzocyclobutenones with Alkynes and activated carbonyls via C-C activation.Nature communications · 2025Article
- Asymmetric Amination of Unstrained C(spJournal of the American Chemical Society · 2024Article
- Catalytic Enantioselective Synthesis of γ-Lactams with β-Quaternary Centers via Merging of C-C Activation and Sulfonyl Radical Migration.Journal of the American Chemical Society · 2022Article
- Dual catalytic enantioselective desymmetrization of allene-tethered cyclohexanones.Chemical science · 2020Article
- Enantioselective Desymmetrization of Cyclobutanones: A Speedway to Molecular Complexity.Angewandte Chemie (International ed. in English) · 2020Review
- Nickel-Catalyzed Asymmetric Domino Ring Opening/Cross-Coupling Reaction of Cyclobutanones via a Reductive Strategy.iScience · 2020Article
- Enantioselective palladium/copper-catalyzed C-C σ-bond activation synergized with Sonogashira-type C(spChemical science · 2019Article
- Catalytic Ring Expansions of Cyclic Alcohols Enabled by Proton-Coupled Electron Transfer.Journal of the American Chemical Society · 2019Article
- Concise Synthesis of (-)-Cycloclavine and (-)-5- epi-Cycloclavine via Asymmetric C-C Activation.Journal of the American Chemical Society · 2018Article
- Distal-Bond-Selective C-C Activation of Ring-Fused Cyclopentanones: An Efficient Access to Spiroindanones.Angewandte Chemie (International ed. in English) · 2017Article
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Authors and funding
2 authors.
Funding
Abstract
Herein an intramolecular nickel-catalyzed (4+2) coupling between cyclobutanones and allenes, by C-C cleavage, is reported. The reaction provides a distinct approach for accessing [3.2.2] bicyclic scaffolds which are challenging to prepare through conventional approaches. The reaction is efficient, chemoselective, and pH/redox neutral. Room temperature conditions and low catalyst loadings can be adopted. Excellent enantioselectivity is also achieved.
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Registered trials
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