Evidence map›Paper›PMID 27813028›Full record

ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2017

The role of serial FDG PET for assessing therapeutic response in patients with cardiac sarcoidosis.

Pei-Ing Lee, Gang Cheng, Abass Alavi

Abstract readEvaluation Study
PubMed Publisher
In one paragraph

Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Diagnostic performance of F-18 FDG PET for detection of cardiac sarcoidosis; A systematic review and meta-analysis.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020
    Pooled it
  2. Article
  3. Article
  4. Cardiac sarcoidosis treated with nonsteroidal immunosuppressive therapy.International journal of cardiology. Heart & vasculature · 2024
    Article
  5. Current uses and understanding of PET imaging in cardiac sarcoidosis.American journal of nuclear medicine and molecular imaging · 2024
    Review
  6. Use of PET/CT to detect myocardial inflammation and the risk of malignant arrhythmia in chronic Chagas disease.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023
    Article
  7. Review
  8. Prednisone vs methotrexate in treatment naïve cardiac sarcoidosis.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023
    Article
  9. Article
  10. FDG uptake patterns in isolated and systemic cardiac sarcoidosis.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023
    Article
  11. Hot spot imaging in cardiovascular diseases: an information statement from SNMMI, ASNC, and EANM.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023
    Article
  12. Article
  13. Cardiac sarcoidosis: the role of cardiac MRI andThe British journal of cardiology · 2023
    Article
  14. Investigating the treatment phenotypes of cardiac sarcoidosis: A prospective cohort study.American heart journal plus : cardiology research and practice · 2022
    Article
  15. Review
  16. Article
  17. Article
  18. Assessing severity of cardiac sarcoid: Is SUV the answer?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020
    Article
  19. Management of Cardiac Sarcoidosis in 2020.Arrhythmia & electrophysiology review · 2020
    Review
  20. The prognostic value of quantitating and localizing F-18 FDG uptake in cardiac sarcoidosis.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Pei-Ing LeeDepartment of Nuclear Medicine, Koo-Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan.
Gang ChengDepartment of Radiology, Philadelphia VA Medical Center, Philadelphia, PA, USA. gangcheng99@yahoo.com.
Abass AlaviDepartment of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe purpose of this study was to determine the feasibility of serial quantitative 2-deoxy-2-[18F]fluoro-D-glucose (FDG) positron emission tomography (PET) to monitor the response of cardiac sarcoidosis to treatment. METHODS AND

resultsA total of 38 PET scan intervals (54 PET scans) were obtained in 16 patients with cardiac sarcoidosis who underwent serial FDG PET during treatment. FDG-avid lesions of the heart were interpreted quantitatively using 4 PET parameters: maximum standardized uptake value (SUVmax), partial volume corrected mean standardized uptake value (SUVmean), partial volume corrected metabolic volume product (MVP), and global metabolic volume product (gMVP). Clinical response to treatment (improved, stable, or progressive disease) was evaluated by clinical symptoms, NYHA class, and EKG in all the patients. SUVmax, SUVmean, MVP, and gMVP had significantly decreased value on repeat PET in patients who were either stable or showed clinical improvement between two serial PET scans, while none of them had significant change on repeat PET in patients who were clinically worse. Correlation analysis between PET findings and clinical assessment revealed that the changes of SUVmax and SUVmean on repeat PET were negatively correlated with patient's clinical outcome.

conclusionOur results indicated that serial FDG PET is feasible to determine the extent of disease activity and to quantitatively assess the response of cardiac sarcoidosis to therapy.

Indexed as

Fluorodeoxyglucose F18CardiomyopathiesDrug MonitoringFemaleHumansImmunosuppressive AgentsLongitudinal StudiesMalePositron-Emission TomographyPrognosisRadiopharmaceuticalsReproducibility of ResultsRetrospective StudiesSarcoidosisSensitivity and SpecificitySubtraction TechniqueFluorodeoxyglucose F18Immunosuppressive AgentsRadiopharmaceuticalsCardiac sarcoidosisFDG PETmetabolic volume productstandardized uptake value

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.